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Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition
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نویسنده
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zeng z. ,shaffer j.r. ,wang x. ,feingold e. ,weeks d.e. ,lee m. ,cuenco k.t. ,wendell s.k. ,weyant r.j. ,crout r. ,mcneil d.w. ,marazita m.l.
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منبع
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journal of dental research - 2013 - دوره : 92 - شماره : 5 - صفحه:432 -437
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چکیده
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While genetics clearly influences dental caries risk,few caries genes have been discovered and validated. recent studies have suggested differential genetic factors for primary dentition caries and permanent dentition caries,as well as for pit-and-fissure- (pf) and smooth- (sm) surface caries. we performed separate gwas for caries in permanent-dentition pf surfaces (1,017 participants,adjusted for age,sex,and the presence of streptococcus mutans) and sm surfaces (1,004 participants,adjusted for age,education group,and the presence of streptococcus mutans) in self-reported whites (ages 14 to 56 yrs). caries scores were derived based on visual assessment of each surface of each tooth; more than 1.2 million snps were either successfully genotyped or imputed and were tested for association. two homologous genes were suggestively associated: bcor (xp11.4) in pf-surface caries (p value = 1.8e-7),and bcorl1 (xq26.1) in sm-surface caries (p value = 1.0e-5). bcor mutations cause oculofaciocardiodental syndrome,a mendelian disease involving multiple dental anomalies. associations of other plausible cariogenesis genes were also observed for pf-surface caries (e.g.,inhba,p value = 6.5e-6) and for sm-surface caries (e.g.,cxcr1 and cxcr2,p value = 1.9e-6). this study supports the notion that genes differentially affect cariogenesis across the surfaces of the permanent dentition,and nominates several novel genes for investigation. © 2013 international & american associations for dental research.
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کلیدواژه
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BCOR; BCORL1; cariogenesis; genetics; genomics; tooth decay
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آدرس
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department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, department of oral biology,school of dental medicine,university of pittsburgh,pittsburgh,pa, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, department of oral biology,school of dental medicine,university of pittsburgh,pittsburgh,pa, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,department of oral biology,school of dental medicine,university of pittsburgh,pittsburgh,pa, United States, department of oral biology,school of dental medicine,university of pittsburgh,pittsburgh,pa, United States, department of dental public health and information management,school of dental medicine,university of pittsburgh,pittsburgh,pa, United States, department of periodontics,school of dentistry,west virginia university,morgantown,wv, United States, dental practice and rural health,west virginia university,morgantown,wv, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,department of oral biology,school of dental medicine,university of pittsburgh,pittsburgh,pa,united states,clinical and translational science,school of medicine,university of pittsburgh,pittsburgh,pa, United States
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Authors
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