Calcium-phosphate-coated oral implants promote osseointegration in osteoporosis

Osteoporotic conditions are anticipated to affect the osseointegration of dental implants. this study aimed to evaluate the effect of a radiofrequent magnetron-sputtered calcium phosphate (cap) coating on dental implant integration upon installment in the femoral condyles of both healthy and osteoporotic rats. at 8 weeks post-implantation,bone volume and histomorphometric bone area were lower around non-coated implants in osteoporotic rats compared with healthy rats. interestingly,push-out tests revealed significantly enhanced implant fixation for cap-coated compared with non-coated implants in both osteoporotic (i.e.,2.9-fold) and healthy rats (i.e.,1.5-fold),with similar implant fixation for cap-coated implants in osteoporotic conditions compared with that of non-coated implants in healthy conditions. further,the presence of a cap coating significantly increased bone-to-implant contact compared with that in non-coated implants in both osteoporotic (i.e.,1.3-fold) and healthy rats (i.e.,1.4-fold). sequential administration of fluorochrome labels showed significantly increased bone dynamics close to cap-coated implants at 3 weeks of implantation in osteoporotic conditions and significantly decreased bone dynamics in osteoporotic compared with healthy conditions. in conclusion,analysis of the data obtained demonstrated that dental implant modification with a thin cap coating effectively improves osseointegration in both healthy and osteoporotic conditions. © international & american associations for dental research.