Genetic networks in osseointegration

Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. the success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however,the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore,implant-induced bone formation continues to be intensively investigated. increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. this review highlights genetic networks related to bone quality,the transient chondrogenic phase,the vitamin d axis,and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration. © international & american associations for dental research.