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Genetic networks in osseointegration
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نویسنده
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nishimura i.
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منبع
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journal of dental research - 2013 - دوره : 92 - شماره : 12 - صفحه:109S -118S
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چکیده
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Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. the success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however,the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore,implant-induced bone formation continues to be intensively investigated. increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. this review highlights genetic networks related to bone quality,the transient chondrogenic phase,the vitamin d axis,and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration. © international & american associations for dental research.
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کلیدواژه
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bone remodeling; cartilage matrix protein; circadian rhythm; dental implants; gene expression; microarray analysis
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آدرس
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weintraub center for reconstructive biotechnology,divisions of advanced prosthodontics and oral medicine and biology,ucla school of dentistry,los angeles,ca 90095-1668, United States
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Authors
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