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   investigating the feasibility of gap prepulse inhibition by auditory middle latency responses in healthy subjects  
   
نویسنده seraji hossein ,mohammadkhani ghassem ,afzalzadeh mohamad reza
منبع auditory and vestibular research - 2024 - دوره : 33 - شماره : 4 - صفحه:330 -338
چکیده    Background and aim: gap prepulse inhibition (gpi) is a type of prepulse inhibition (ppi) in which a gap is used as a prepulse. this study was conducted to investigate the silence gap effect on auditory middle latency response (amlr) inhibition in normal subjects. methods: in this study, 25 participants with normal hearing and no history of tinnitus were included. amlr was recorded in response to stimuli with gap and without gap in two background noises of 2 and 8 khz at two electrode locations fz and cz and then, gap prepulse inhibition for na-pa, pa-nb, nb-pb and pb-nc amplitude with use of responses to stimuli with and without gap was calculated. results: the results showed that the mean amplitudes of all four amlr indices decreased in response to the stimuli with gap and this decrease was more and statistically significant in 8 khz background noise (p≤0.001). conclusion: according to the results of this study, it seems that in future studies, ppi of na-pa and pb-nc amplitudes can be used as main indicators and ppi of pa-nb and nb-pb amplitudes as alternative indicators in the ppi paradigm in tinnitus diagnosis.
کلیدواژه prepulse inhibition ,tinnitus ,auditory middle latency responses
آدرس tehran university of medical sciences, school of rehabilitation, department of audiology, iran, tehran university of medical sciences, school of rehabilitation, department of audiology, iran, mashhad university of medical sciences, faculty of medicine, department of otorhinolaryngology, iran
پست الکترونیکی afzalzadehmr@mums.ac.ir
 
     
   
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