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efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents
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نویسنده
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fu d.-j. ,hou y.-h. ,zhang s.-y. ,zhang y.-b.
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منبع
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journal of chemical sciences - 2018 - دوره : 130 - شماره : 1
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چکیده
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Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. the target sulfonamide hybrids were obtained in the click reaction of azide derivatives and commerciallly available alkynes. all sulfonamide hybrids were evaluated for their antiproliferative activity against three selected cancer cell lines (mgc-803, ec-109 and pc-3). most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. particularly, compound 8c showed the potent antiproliferative activity with an ic 50 value of 0.7μmol against mgc-803 cancer cells. these sulfonamide hybrids might be promising lead compounds to develop antitumor agents in the clinical practice. graphical abstract : synopsis. twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. these sulfonamide hybrids were synthesized by click reaction and evaluated for their antiproliferative activity. among them, compound 8c showed potent antiproliferative activity with an ic 50 value of 0.7μmol against mgc-803 cells. [figure not available: see fulltext.]. © 2018, indian academy of sciences.
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کلیدواژه
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antiproliferative ,click reaction ,molecular hybridization strategy ,sulfonamide
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آدرس
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ministry of education, zhengzhou university, new drug research & development center, school of pharmaceutical sciences, key laboratory of technology of drug preparation, key laboratory of henan province for drug quality and evaluation, china. collaborative innovation center of new drug research and safety evaluation, china, ministry of education, zhengzhou university, new drug research & development center, school of pharmaceutical sciences, key laboratory of technology of drug preparation, key laboratory of henan province for drug quality and evaluation, china. collaborative innovation center of new drug research and safety evaluation, china, zhengzhou university, school of basic medical sciences, china, ministry of education, zhengzhou university, new drug research & development center, school of pharmaceutical sciences, key laboratory of technology of drug preparation, key laboratory of henan province for drug quality and evaluation, china. collaborative innovation center of new drug research and safety evaluation, china
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Authors
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