Protective effect of pomegranate peel ethanol extract against ferric nitrilotriacetate induced renal oxidative damage in rats

Pomegranate is an important source of bioactive compounds. the nephroprotective effect of pomegranate peel ethanol extract against ferric nitrilotriacetate (fe-nta)-induced renal oxidative stress was studied. the results showed that fe-nta enhances renal lipid peroxidation with reduction in renal glutathione content,antioxidant enzymes,viz.,glutathione peroxidase,catalase,glutathione reductase and phase-ii metabolizing enzyme,glutathione-s-transferase. it also enhances serum urea and creatinine. treatment of rats orally with pomegranate peel extract (100 and 200 mg/kg/day,for seven days) resulted in significant decrease in lipid peroxidation and serum urea and creatinine levels. renal glutathione content,glutathione-s-transferase and antioxidant enzymes were also recovered to a significant level (p<0.05). the obtained data demonstrate that pomegranate peel ethanol extract is a potent nephroprotective agent and suppresses fe-nta-induced renal oxidative damage in rats.