Lead induced alterations in blood cell counts and hemoglobin during gestation and lactation in Swiss albino mice [Swiss albino farelerde gebelik ve süt verme süresince kurşun ile tetiklenen hemoglobin ve kan hücreleri sayi{dotless}lari{dotless}ndaki deǧişimler]

Although a number of studies in animal models have shown changes in hemoglobin content and blood cell counts after lead administration during gestation and lactation,lead induced hematological changes are not well established. in the present study,hemoglobin content and blood cells of normal and lead exposed pregnant and lactating swiss mice were compared in which selected pregnant females were treated with lead acetate by gavages (266.66,533.33,1066.66 mg/kg bw) during gestation and lactation. animals were exposed to heavy metal lead orally from day 10 of gestation to 3 rd weeks of lactation. hemoglobin content and blood cell counts were examined on 17 th day of gestation and on 1 st,7 th,14 th and 21 st day after birth. the results indicated that in lead intoxicated pregnant females,hemoglobin content and red blood cell (rbc) counts decreased and white blood cell (wbc) counts increased. from the results of above study it can be concluded that high levels of lead exposure during gestation and lactation can severely damage heme synthesis and alter the number of rbc and wbc.