Decision making mechanism influences the regulatory function of notch in apoptosis [karar verme mekanizmasi{dotless} notch'un apoptozdaki düzenleyici rolünü setkiler]

The anti-apoptotic role of notch and its interactors has been cited by many in the recent past. this intriguing phenomenon however involves a non-canonical pathway that is independent of the usual nuclear-localization of the notch intracellular domain (nicd) which is formed following a series of cleavage events set off by the ligand dependent activation of the notch receptor. this finding has in turn led to the general postulation that there is perhaps a membrane-tethered or cytoplasm localized form of nicd which is responsible for its non-canonical pathway. however,this notion has been a subject of scrutiny from the moment of its origin. this review will make an attempt to compile most of these current ambiguities and will furthermore try to substantiate,a likely evolutionary significance of the regulatory function of notch on apoptosis,by using the theory of natural selection to intervene.