The effects of aqueous and ethanolic leaf extracts of Vernonia amygdalina on some vital organs in adult wistar rats [Vernonia amygdalina yapraǧi{dotless}ni{dotless}n sulu ve etanolik özütlerinin erişkin wistar si{dotless}çanlari{dotless}ni{dotless}n bazi{dotless} hayati organlari{dotless}na etkileri]

The aim of this study was to comparatively determine the effects of aqueous and ethanolic extracts of vernonia amygdalina (asteraceae) leaves,adopting histological procedures on the liver,stomach and kidney in adult wistar rats.there were four groups of animals: a,b,c and d. groups a,b and c served as the treated animals while group d served as the control animals. each of the groups was further subdivided into two i.e a1 & a2; b1 & b2; c1 & c2 and d1 & d2. animals in groups a1,b1 and c1 were administered orally with aqueous extract of v. amygdalina 100,200 and 300 mg/kg respectively while animals in groups a2,b2 and c2 were administered orally with ethanolic extract of v. amygdalina 100,200 and 300 mg/kg respectively. the control groups,d1 and d2,received equal volume of normal saline. there were no significant derangement in the cy toarchitecture of the stomach,liver and kidney. rather,the cy toarchitecture of the animals treated with both the ethanolic and aqueous extracts (300mg/kg) of v. amygdalina were better organized when compared with the control. it was therefore concluded that both ethanolic and aqueous leaf extracts of v. amygdalina are non-toxic and may possess cytoprotective potential.