Transforming acidic coiled-coil proteins and spindle assembly [Dönüştürücü asidik sarmalanmi{dotless}ş sarmal proteinleri ve iǧ iplikçiǧinin birleşmesi]

Transforming acidic coiled-coil proteins (tacc) are essential for mitosis not only by their association with the centrosome and assembly of spindle microtubules,but also by involvement in cell cycle checkpoints. in order to stabilize spindle fibers,taccs interact with other microtubule-associated proteins (maps). dysregulation of taccs may lead to abnormal cell division that may result in chromosomal abnormality or tumorigenesis. this review focuses on facts known so far regarding tacc proteins,their interactions and their involvement in spindle microtubule stability in higher eukaryotes.