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Intra-thoracic fat volume is associated with myocardial infarction in patients with metabolic syndrome
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نویسنده
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jolly u.s. ,soliman a. ,mckenzie c. ,peters t. ,stirrat j. ,nevis i. ,brymer m. ,joy t. ,drangova m. ,white j.a.
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منبع
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journal of cardiovascular magnetic resonance - 2013 - دوره : 15 - شماره : 1
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چکیده
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Background: visceral adiposity is increased in those with metabolic syndrome (mets) and atherosclerotic disease burden. in this study we evaluate for associations between intra-thoracic fat volume (itfv) and myocardial infarction (mi) in patients with mets. methods. ninety-four patients with mets,mi or both were identified from a cardiovascular cmr clinical registry. mets was defined in accordance to published guidelines; where-as mi was defined as the presence of subendocardial-based injury on late gadolinium enhancement imaging in a coronary vascular distribution. a healthy control group was also obtained from the same registry. patients were selected into the following groups: mets+/mi- (n = 32),mets-/mi + (n = 30),mets+/mi + (n = 32),mets-/mi- (n = 16). itfv quantification was performed using signal threshold analysis of sequential sagittal cmr datasets (haste) and indexed to body mass index. results: the mean age of the population was 59.8 ± 12.5 years. mets+ patients (n=64) demonstrated a significantly higher indexed itfv compared to mets- patients (p = 0.05). patients in respective mets-/mi-,mets+/mi-,mets-/mi+,and mets+/mi + study groups demonstrated a progressive elevation in the indexed itfv (22.3 ± 10.6,28.6 ± 12.6,30.6 ± 12.3,and 35.2 ± 11.4 ml/kg/m2,(p = 0.002)). among mets+ patients those with mi showed a significantly higher indexed itfv compared to those without mi (p = 0.02). conclusions: itfv is elevated in patients with mets and incrementally elevated among those with evidence of prior ischemic myocardial injury. accordingly,the quantification of itfv may be a valuable marker of myocardial infarction risk among patients with mets and warrants further investigation. © 2013 jolly et al.; licensee biomed central ltd.
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کلیدواژه
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Adiposity; Fat distribution; Metabolic syndrome; Myocardial infarction
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آدرس
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department of medicine,schulich school of medicine and dentistry,university of western ontario,london,on, Canada, robarts research institute,university of western ontario,london,on,canada,biomedical engineering,university of western ontario,london,on, Canada, robarts research institute,university of western ontario,london,on,canada,lawson health research institute,university of western ontario,london,on,canada,department of medical biophysics,university of western ontario,london,on, Canada, robarts research institute,university of western ontario,london,on,canada,lawson health research institute,university of western ontario,london,on,canada,department of medical biophysics,university of western ontario,london,on, Canada, robarts research institute,university of western ontario,london,on, Canada, robarts research institute,university of western ontario,london,on, Canada, robarts research institute,university of western ontario,london,on, Canada, department of medicine,schulich school of medicine and dentistry,university of western ontario,london,on,canada,robarts research institute,university of western ontario,london,on, Canada, robarts research institute,university of western ontario,london,on,canada,department of medical biophysics,university of western ontario,london,on, Canada, department of medicine,schulich school of medicine and dentistry,university of western ontario,london,on,canada,robarts research institute,university of western ontario,london,on,canada,lawson health research institute,university of western ontario,london,on,canada,cardiovascular mri clinical research (cmcr) program,london health sciences center,339 windermere road,london,on n6a 5a5, Canada
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Authors
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