Evaluation of diastolic function by three-dimensional volume tracking of the mitral annulus with cardiovascular magnetic resonance: Comparison with tissue Doppler imaging

Background: measurement of mitral annulus (ma) dynamics is an important component of the evaluation of left ventricular (lv) diastolic function; ma velocities are commonly measured using tissue doppler imaging (tdi). this study aimed to examine the clinical potential of a semi-automated cardiovascular magnetic resonance (cmr) technique for quantifying global lv diastolic function,using 3d volume tracking of the ma with conventional cine-cmr images.methods. 124 consecutive patients with normal ejection fraction underwent both clinically indicated transthoracic echocardiography (tte) and cmr within 2 months. interpolated 3d reconstruction of the ma over time was performed with semi-automated atrioventricular junction (avj) tracking in long-axis cine-cmr images,producing an ma sweep volume over the cardiac cycle. cmr-based diastolic function was evaluated,using the following parameters: peak volume sweep rates in early diastole (psre) and atrial systole (psra),psre/psraratio,deceleration time of sweep volume (dtsv),and 50% diastolic sweep volume recovery time (dsvrt50); these were compared with tte diastolic measurements.results: patients with tte-based diastolic dysfunction (n = 62) showed significantly different normalized ma sweep volume profiles compared to those with tte-based normal diastolic function (n = 62),including a lower psre(5.25 ± 1.38 s-1vs. 7.72 ± 1.7 s-1),a higher psra(6.56 ± 1.99 s-1vs. 4.67 ± 1.38 s-1),a lower psre/psraratio (0.9 ± 0.44 vs. 1.82 ± 0.69),a longer dtsv(144 ± 55 ms vs. 96 ± 37 ms),and a longer dsvrt50(25.0 ± 11.0% vs. 15.6 ± 4.0%) (all p < 0.05). cmr diastolic parameters were independent predictors of tte-based diastolic dysfunction after adjusting for left ventricular hypertrophy,hypertension,and coronary artery disease. good correlations were observed between cmr psre/psraand early-to-late diastolic annular velocity ratios (e′/a′) measured by tdi (r = 0.756 to 0.828,p < 0.001).conclusions: 3d ma sweep volumes generated by semi-automated avj tracking in routinely acquired cmr images yielded diastolic parameters that were effective in identifying patients with diastolic dysfunction when correlated with tte-based variables. © 2014 wu et al.; licensee biomed central ltd.