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2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry
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نویسنده
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bruder o. ,schneider s. ,pilz g. ,van rossum a.c. ,schwitter j. ,nothnagel d. ,lombardi m. ,buss s. ,wagner a. ,petersen s. ,greulich s. ,jensen c. ,nagel e. ,sechtem u. ,mahrholdt h.
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منبع
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journal of cardiovascular magnetic resonance - 2015 - دوره : 17 - شماره : 1
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چکیده
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Objectives: specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population. background: we sought to re-evaluate the frequency,manifestations,and severity of acute adverse reactions associated with administration of several gadolinium- based contrast agents during routine cmr on a european level. methods: multi-centre,multi-national,and multi-ethnical registry with consecutive enrolment of patients in 57 european centres. results: during the current observation 37788 doses of gadolinium based contrast agent were administered to 37788 patients. the mean dose was 24.7 ml (range 5-80 ml),which is equivalent to 0.123 mmol/kg (range 0.01 - 0.3 mmol/kg). forty-five acute adverse reactions due to contrast administration occurred (0.12 %). most reactions were classified as mild (43 of 45) according to the american college of radiology definition. the most frequent complaints following contrast administration were rashes and hives (15 of 45),followed by nausea (10 of 45) and flushes (10 of 45). the event rate ranged from 0.05 % (linear non-ionic agent gadodiamide) to 0.42 % (linear ionic agent gadobenate dimeglumine). interestingly,we also found different event rates between the three main indications for cmr ranging from 0.05 % (risk stratification in suspected cad) to 0.22 % (viability in known cad). conclusions: the current data indicate that the results of the earlier safety data hold true in this much larger multi-national and multi-ethnical population. thus,the off-label use of gadolinium based contrast in cardiovascular mr should be regarded as safe concerning the frequency,manifestation and severity of acute events. © 2015 bruder et al.
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کلیدواژه
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Off-label use; Cardiovascular magnetic resonance; Gadolinium; Safety
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آدرس
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department of cardiology and angiology,elisabeth hospital,essen, Germany, institut für herzinfarktforschung,department of biometrics,ludwigshafen, Germany, department of cardiology,hospital agatharied,hausham, Germany, department of cardiology,vu university medical centre,amsterdam, Netherlands, centre hospitalier universitaire vaudois - chuv university of lausanne,lausanne, Switzerland, department of cardiology,klinikum ludwigsburg,ludwigsburg, Germany, fondazione c.n.r./regione toscana g. monasterio,pisa, Italy, department of cardiology,university of heidelberg,heidelberg, Germany, cardiology associates of fairfield,stamford,ct, United States, barts and the london nihr biomedical research unit,london chest hospital,london, United Kingdom, department of cardiology,robert bosch medical centre,stuttgart,70376, Germany, department of cardiology and angiology,elisabeth hospital,essen, Germany, division of cardiovascular imaging,j.w. goethe university frankfurt,frankfurt am main,germany,german center of cardiovascular research,frankfurt, Germany, department of cardiology,robert bosch medical centre,stuttgart,70376, Germany, department of cardiology,robert bosch medical centre,stuttgart,70376, Germany
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Authors
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