|
|
|
|
Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: A cross-sectional study in patients hospitalized with acute heart failure
|
|
|
|
|
|
|
|
نویسنده
|
liao p.-a. ,lin g. ,tsai s.-y. ,wang c.-h. ,juan y.-h. ,lin y.-c. ,wu m.-t. ,yang l.-y. ,liu m.-h. ,chang t.-c. ,lin y.-c. ,huang y.-c. ,huang p.-c. ,wang j.-j. ,ng s.-h. ,ng k.-k.
|
|
منبع
|
journal of cardiovascular magnetic resonance - 2016 - دوره : 18 - شماره : 1
|
|
چکیده
|
Background: increased myocardial triglyceride (tg) content has been recognized as a risk factor for cardiovascular disease. however,its relation with cardiac function in patients on recovery from acute heart failure (hf) remains unclear. in this cross-sectional study,we sought to investigate the association between myocardial tg content measured on magnetic resonance spectroscopy (1h-mrs) and left ventricular (lv) function assessed on cardiovascular magnetic resonance (cmr) in patients who were hospitalized with hf. methods: a total of 50 patients who were discharged after hospitalization for acute hf and 21 age- and sex-matched controls were included in the study. myocardial tg content and lv parameters (function and mass) were measured on a 3.0 t mr scanner. fatty acid (fa) and unsaturated fatty acid (ufa) content was normalized against water (w) using the lc-model algorithm. the patient population was dichotomized according to the left ventricular ejection fraction (lvef,<50 % or ≥ 50 %). results: h-mrs data were available for 48 patients and 21 controls. of the 48 patients,25 had a lvef <50 % (mean,31.2 %),whereas the remaining 23 had a normal lvef (mean,60.2 %). myocardial ufa/w ratio was found to differ significantly in patients with low lvef,normal lvef,and controls (0.79 % vs. 0.21 % vs. 0.14 %,respectively,p = 0.02). the myocardial ufa/tg ratio was associated with lv mass (r = 0.39,p < 0.001) and modestly related to lv end-diastolic volume (lvedv; r = 0.24,p = 0.039). we also identified negative correlations of the myocardial fa/tg ratio with both lv mass (r = -0.39,p < 0.001) and lvedv (r = -0.24,p = 0.039). conclusions: as compared with controls,patients who were discharged after hospitalization for acute hf had increased myocardial ufa content; furthermore,ufa was inversely related with lvef,lv mass and,to a lesser extent,lvedv. our study may stimulate further research on the measure of myocardial ufa content by 1h-mrs for outcome prediction. © 2016 liao et al.
|
|
کلیدواژه
|
Cardiovascular magnetic resonance; Heart failure; Left ventricular systolic function; Magnetic resonance spectroscopy; Myocardial triglyceride content
|
|
آدرس
|
department of medical imaging and intervention,chang gung memorial hospital,linkou and chang gung university,5 fuhsing street,gueishan,taoyuan,333, Taiwan, department of medical imaging and intervention,chang gung memorial hospital,linkou and chang gung university,5 fuhsing street,gueishan,taoyuan,333,taiwan,institute for radiological research,chang gung university,taoyuan, Taiwan, graduate institute of applied physics,national chengchi university,taipei, Taiwan, department of cardiology and heart failure center,chang gung memorial hospital,keelung, Taiwan, department of medical imaging and intervention,chang gung memorial hospital,linkou and chang gung university,5 fuhsing street,gueishan,taoyuan,333, Taiwan, department of radiology,chang gung memorial hospital,keelung and chang gung university,keelung, Taiwan, department of radiology,kaohsiung veterans general hospital,kaohsiung, Taiwan, clinical trial center,chang gung memorial hospital at linkou,taoyuan, Taiwan, department of cardiology and heart failure center,chang gung memorial hospital,keelung, Taiwan, department of radiology,chang gung memorial hospital,keelung and chang gung university,keelung, Taiwan, department of medical imaging and intervention,chang gung memorial hospital,linkou and chang gung university,5 fuhsing street,gueishan,taoyuan,333, Taiwan, department of radiology,chang gung memorial hospital,keelung and chang gung university,keelung, Taiwan, department of medical imaging and intervention,chang gung memorial hospital,linkou and chang gung university,5 fuhsing street,gueishan,taoyuan,333, Taiwan, institute for radiological research,chang gung university,taoyuan, Taiwan, department of medical imaging and intervention,chang gung memorial hospital,linkou and chang gung university,5 fuhsing street,gueishan,taoyuan,333, Taiwan, department of radiology,chang gung memorial hospital,keelung and chang gung university,keelung, Taiwan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|