Aortic atheroma as a source of stroke - Assessment of embolization risk using 3D CMR in stroke patients and controls

Background: it was our purpose to identify vulnerable plaques in the thoracic aorta using 3d multi-contrast cmr and estimate the risk of cerebral embolization using 4d flow cmr in cryptogenic stroke patients and controls. methods: one hundred patients (40 with cryptogenic stroke,60 ophthalmologic controls matched for age,sex and presence of hypertension) underwent a novel 3d multi-contrast (t1w,t2w,pdw) cmr protocol at 3 tesla for plaque detection and characterization within the thoracic aorta,which was combined with 4d flow cmr for mapping potential embolization pathways. plaque morphology was assessed in consensus reading by two investigators and classified according to the modified american-heart-association (aha) classification of atherosclerotic plaques. results: in the thoracic aorta,plaques <4 mm thickness were found in a similar number of stroke patients and controls [23 (57.5%) versus 33 (55.0%); p = 0.81]. however,plaques ≥4 mm were more frequent in stroke patients [22 (55.0%) versus 10 (16.7%); p < 0.001]. of those patients with plaques ≥4 mm,seven (17.5%) stroke patients and two (3.3%) controls (p < 0.001) had potentially vulnerable aha type vi plaques. six stroke patients with vulnerable aha tiype vi plaques ≥4 mm had potential embolization pathways connecting the plaque,located in the aortic arch (n = 3) and proximal descending aorta (n = 3),with the individual territory of stroke,which made them the most likely source of stroke in those patients. conclusions: our findings underline the significance of ≥4 mm thick and vulnerable plaques in the aortic arch and descending aorta as a relevant etiology of stroke. clinical trial registration: unique identifier: drks00006234; date of registration: 11/06/2014 © 2017 the author(s).