|
|
|
|
CXCl16 in vascular pathology research: From macro effects to microRNAs
|
|
|
|
|
|
|
|
نویسنده
|
jovanović i. ,zivković m. ,djurić t. ,popović m. ,alavantić d. ,stanković a.
|
|
منبع
|
journal of atherosclerosis and thrombosis - 2015 - دوره : 22 - شماره : 10 - صفحه:1012 -1024
|
|
چکیده
|
Chemokines and their receptors have become significant factors in atherosclerosis research. cxcl16 is a multifunctional agent located on a separate locus to all other known chemokines and binds only to its “unique” receptor named cxcr6. as a scavenger receptor,adhesion molecule,and chemokine,it quickly became an interesting target in atherosclerosis research as all its functions have a role in vascular pathology. the investigation of the role of cxcl16 in atherosclerosis,although shown in in vitro studies,animal knockout models,and cxcl16 gene polymorphisms,haplotypes,and circulating levels,still shows puzzling results. genetic and epigenetic studies have just scratched the surface of research necessary for a better assessment of the significance and perspective of this marker in plaque development and progression. in this review,we will summarize current knowledge about cxcl16 in atherosclerosis. additionally,we will point out the importance of bioinformatics tools for the detection of potentially new cxcl16 regulatory networks through microrna activity. this review aims to provide a better understanding of the underlying mechanisms,define more specific biomarkers,and discover new therapeutic targets. © 2015,japan atherosclerosis society. all rights reserved.
|
|
کلیدواژه
|
Atherosclerosis; CXCL16 chemokine; Expression; Gene; MicroRNA
|
|
آدرس
|
vinča institute of nuclear sciences,laboratory for radiobiology and molecular genetics,university of belgrade,belgrade, Serbia, vinča institute of nuclear sciences,laboratory for radiobiology and molecular genetics,university of belgrade,belgrade, Serbia, vinča institute of nuclear sciences,laboratory for radiobiology and molecular genetics,university of belgrade,belgrade, Serbia, vinča institute of nuclear sciences,laboratory for radiobiology and molecular genetics,university of belgrade,belgrade,serbia,david h. smith center for vaccine biology and immunology,department of microbiology and immunology,university of rochester,rochester,ny, United States, vinča institute of nuclear sciences,laboratory for radiobiology and molecular genetics,university of belgrade,belgrade, Serbia, vinča institute of nuclear sciences,laboratory for radiobiology and molecular genetics,university of belgrade,belgrade, Serbia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|