Levels of circulating microparticles in patients with chronic cardiorenal disease

Aim: cardiac and renal diseases are common disorders that frequently coexist. we tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (eda-mps; cd31+cd42b−an−v+) and platelet-derived apoptotic microparticles (pda-mps; cd31+cd42b+an−v+) are useful biomarkers for predicting the presence of cardiorenal disease (crd). methods: a total of 68 patients with chronic kidney disease (ckd) and angina pectoris (ckd-ap) undergoing cardiac catheterization were prospectively enrolled into group 1,10 patients with coronary artery disease (cad) without ckd were enrolled into group 2 (cad+ckd−) and 10 patients without cad and ckd were enrolled into group 3 (cad−ckd−). results: the serum creatinine levels were significantly higher,whereas the estimated glomerular filtration rates (egfrs) were significantly lower,in group 1 than in the other two groups (all p<0.02). the circulating levels of eda-mps and pda-mps did not differ between the patients with and without ckd (all p>0.2). however,the circulating levels of eda-mps and pda-mps were significantly higher in group 2 than in groups 1 and 3 (all p<0.03). in addition,differences were noted in the circulating eda-mp and pda-mp levels between groups 1 and 3,although without statistical significance (all p>0.09). meanwhile,among the ckd patients,the subgroup analysis showed that the levels of mps were significantly higher in those with cad than in those without (all p=0.001),while a multivariate analysis demonstrated that cad was the only factor independently predictive of high levels of circulating eda-mps and pda-mps (p=0.033). conclusions: the link with increased circulating levels of mps is more consistent in patients with cad than in those with ckd. © 2015 japan atherosclerosis society.