High-risk atherosclerotic cardiovascular disease in a real-world employed japanese population: Prevalence,cardiovascular event rates,and costs

Aim: to assess the prevalence of high-risk atherosclerotic cardiovascular disease (ascvd,defined as history of acute coronary syndrome [hacs],cerebrovascular atherosclerotic disease [cevad],peripheral artery disease [pad],or coronary artery disease w/diabetes [cadd] and associated costs and cardiovascular (cv events in japan. methods: a retrospective analysis was conducted using the japan medical data center (jmdc database (2006 – 2011. ascvd prevalence was estimated on the basis of diagnoses for cevad,pad,cadd,and hacs (acs claim >30–≤365 days after acs-related hospitalization during 1/1/ 2008– 12/31/2009. population denominators used in the prevalence estimations were provided by jmdc. a subcohort with an insurance coverage for ≥12 months before and ≥24 months after first/ index ascvd claim during 1/1/2008–12/31/2009 were analyzed on the basis of costs (in 2012 us dollars and events. results: ascvd prevalence was 1,869/100,000 population. in total,8,112 patients met inclusion criteria for the cost and cv event analyses. among these patients,4.0% experienced any event (myocardial infarction,stroke,coronary revascularization,hospitalization for unstable angina in the year after ascvd diagnosis,which decreased to 2.2% in year 2. first-year event rates were highest (22% in patients with hacs. mean [sd] all-cause costs per patient in year 1 were $7,031 [$14,359] for all patients with ascvd combined. extrapolated to the entire employed population,total first-year costs were estimated at $8.2 billion. conclusions: ascvd is not rare in japan,even within a relatively young population of employed persons. further,the total direct first-year cost burden of ascvd in the employed japanese population is high. these data may inform future economic assessments of new ascvd treatments. © 2015,japan atherosclerosis society. all rights reserved.