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   A trial of Pitavastatin versus Rosuvastatin for Dyslipidemia in chronic kidney disease  
   
نویسنده abe m. ,maruyama n. ,maruyama t. ,okada k. ,soma m.
منبع journal of atherosclerosis and thrombosis - 2015 - دوره : 22 - شماره : 12 - صفحه:1235 -1247
چکیده    Aim: to determine the lipid lowering effectiveness,cost effectiveness,and safety of rosuvastatin compared with pitavastatin in dyslipidemic patients with concurrent renal disorders. methods: this single-center,prospective,open-label,randomized,12-month study evaluated rosuvastatin (2.5 mg and pitavastatin (1 or 2 mg in 134 dyslipidemic patients with concurrent chronic kidney disease (ckd; rosuvastatin group,n = 68; pitavastatin group,n= 66. lipid parameters [i.e.,low density lipoprotein cholesterol (ldl-c,etc.],renal function parameters [i.e.,estimated glomerular filtration rate (egfr,etc.],glycated hemoglobin (hba1c,and high-sensitivity c-reactive protein (hs-crp were measured at enrollment (baseline,month 6,and month 12. results: the mean daily dose of rosuvastatin and pitavastatin was 2.5 mg and 1.4 mg,respectively. all lipid parameters were significantly more improved in the rosuvastatin group. egfr improved from baseline in the rosuvastatin group (p < 0. 0001 and showed no tendency to worsen in the pitavastatin group (p=0. 2232. in multiple regression analysis (n = 134,it was significantly associated with a percent change in total cholesterol (β =0.2296; p = 0. 0112,smoking (β = 0.1927; p = 0. 0224,and hba1c (β = -0.1606; p = 0. 0585. hs-crp was significantly improved in both groups. an analysis eliminating the influence of antidiabetic medication showed a significant difference between groups in the change of hba1c at month 6 from baseline (p = 0. 0016. no subjects in either group had new onset of diabetes mellitus. the cost of statin medication required to reduce ldl-c by 10 mg/dl was significantly lower for 2.5 mg of rosuvastatin (p =0. 0116. conclusions: rosuvastatin 2.5 mg had superior lipid lowering and cost effectiveness in dyslipidemic patients with concurrent ckd. (umin id: umin 000005812 © 2015,japan atherosclerosis society. all rights reserved.
کلیدواژه Cardiovascular disease; Chronic kidney disease; Cost effectiveness; Lipid lowering effectiveness; Statins
آدرس division of nephrology,hypertension,and endocrinology,department of internal medicine,nihon university school of medicine,tokyo, Japan, division of nephrology,hypertension,and endocrinology,department of internal medicine,nihon university school of medicine,tokyo, Japan, division of nephrology,hypertension,and endocrinology,department of internal medicine,nihon university school of medicine,tokyo, Japan, division of nephrology,hypertension,and endocrinology,department of internal medicine,nihon university school of medicine,tokyo, Japan, division of nephrology,hypertension,and endocrinology,department of internal medicine,nihon university school of medicine,tokyo, Japan
 
     
   
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