>
Fa   |   Ar   |   En
   Impact of serum uric acid levels on coronary plaque stability evaluated using integrated backscatter intravascular ultrasound in patients with coronary artery disease  
   
نویسنده ando k. ,takahashi h. ,watanabe t. ,daidoji h. ,otaki y. ,nishiyama s. ,arimoto t. ,shishido t. ,miyashita t. ,miyamoto t. ,kubota i.
منبع journal of atherosclerosis and thrombosis - 2016 - دوره : 23 - شماره : 8 - صفحه:932 -939
چکیده    Aim: because the prevalence of hyperuricemia is lower in females than in males,the association between hyperuricemia and cardiovascular disease has been frequently reported in females. increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension,renal dysfunction,insulin resistance,and metabolic syndrome. however,it is controversial whether hyperuricemia is an independent risk factor for coronary artery disease in both the genders. the purpose of this study was to investigate the relationship between serum uric acid levels and coronary plaque components assessed using integrated backscatter intravascular ultrasound (ib-ivus) in males and females. methods: in total,385 patients (298 males and 87 females) who underwent percutaneous coronary intervention using ib-ivus were divided into three groups in each gender according to their serum uric acid levels. we characterized tissue from coronary plaques in culprit lesions. results: serum uric acid levels significantly correlated with percent lipid volume (r =0.37) and inversely correlated with percent fibrous volume (r =-0.35). multivariate analysis showed that the uric acid level was independently associated with lipid-rich plaques (odds ratio 2.43,95%,confidence interval 1.75-3.47). the prevalence of lipid-rich plaques increased with increasing uric acid levels in both genders. conclusion: increased serum uric acid levels were associated with larger lipid content plaques in both genders. © 2016 japan atherosclerosis society.
کلیدواژه Intravascular ultrasound; Plaque component; Uric acid
آدرس department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan, department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan, department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan, department of cardiology,yamagata prefectural central hospitalyamagata, Japan, department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan, department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan, department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan, department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan, department of cardiology,tohoku pharmaceutical universitymiyagi, Japan, department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan, department of cardiology,pulmonology,and nephrology,yamagata university school of medicineyamagata, Japan
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved