Serum albumin and high-sensitivity C-reactive protein are independent risk factors of chronic kidney disease in middle-aged Japanese individuals: the circulatory risk in communities study

Aim: it is important to explore predictive markers other than conventional cardiovascular risk factors for early detection and treatment of chronic kidney disease (ckd),a major risk factor for end-stage renal failure. we hypothesized that serum albumin and high-sensitivity c-reactive protein (hs-crp) to be independent markers,and examined their associations with the risk of ckd. methods: we examined the associations of serum albumin and hs-crp levels with the risk of incident ckd,in 2535 japanese adults aged 40-69 years without ckd at baseline during a median 9.0-year follow-up after adjustment for known cardiovascular risk factors. results: during the follow-up period,367 cases of ckd developed. in multivariable analyses adjusted for known risk factors,the ckd hazard ratios (95% confidence intervals) for the highest versus lowest quartiles of serum albumin levels were 0.69 (0.40-1.17) for men and 0.42 (0.28-0.64) for women. corresponding values for hs-crp were 0.95 (0.54-1.67) for men and 1.85 (1.25 -2.75) for women. the association of combined serum albumin and hs-crp with the risk of ckd was examined for women. the hazard ratio was 1.72 (1.17-2.54) for low versus higher albumin levels at lower hs-crp levels,but such an association was not observed at high hs-crp level. the hazard ratio was 1.96 (1.44- 2.66) for high versus lower hs-crp levels at higher serum albumin levels,but such association was not observed at low serum albumin level. conclusion: both low serum albumin and high hs-crp levels were predictive of ckd for women. © 2016 japan atherosclerosis society.