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Serum γ-glutamyltransferase and mortality due to cardiovascular disease in Japanese men and women
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نویسنده
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li y. ,iso h. ,cui r. ,murakami y. ,yatsuya h. ,miura k. ,nagasawa s.-y. ,ueshima h. ,okamura t. ,imai y. ,ohkubo t. ,irie f. ,kitamura a. ,kiyohara y. ,nakagawa h. ,nakayama t. ,okayama a. ,sairenchi t. ,saitoh s. ,sakata k. ,tamakoshi a. ,tsuji i. ,yamada m. ,kiyama m. ,miyamoto y. ,ishikawa s.
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منبع
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journal of atherosclerosis and thrombosis - 2016 - دوره : 23 - شماره : 7 - صفحه:792 -799
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چکیده
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Aim: whether the association between serum γ-glutamyltransferase (γ-gtp) levels and total cardiovascular disease (cvd) mortality is independent of alcohol drinking in east asian populations is not well known. we conducted a pooled analysis of japanese men and women that enabled an analysis restricted to never-drinkers. methods: a total of 15,987 men and 25,053 women aged 40-79 years,pooled from seven cohort studies throughout japan,were followed-up to examine sex-specific relationship between serum γ -gtp levels and total cvd mortality. cox regression model was used that was adjusted for age,smoking status,body mass index,and systolic blood pressure and serum triglyceride,total cholesterol,aspartate aminotransferase,and alanine aminotransferase levels. results: during an average follow-up of 8.7 years,we documented 361 and 340 deaths from total cvd,146 and 168 from stroke,and 101 and 53 from coronary heart disease (chd) for men and women,respectively. among the never-drinkers,hazard ratios (hrs) for mortality for one standard deviation of log-γ-gtp for men were 1.89 (1.00-3.58) for stroke,1.04 (0.57-1.90) for chd,and 1.43 (1.04-1.96) for total cvd. for women,hrs were 1.28 (1.06-1.54),1.81 (1.34-2.44),and 1.30 (1.14-1.49),respectively. conclusion: γ-gtp may be a risk factor for total cvd mortality independent of alcohol drinking status in japanese men and women. © 2016,japan atherosclerosis society. all rights reserved.
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کلیدواژه
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Cardiovascular disease; Coronary heart disease; Epidemiology; Stroke; γ-glutamyltransferase
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آدرس
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department of public health,fujita health university,school of medicine,aichi, Japan, department of social and environmental medicine,osaka university graduate school of medicine,osaka,japan,osaka university graduate school of medicine, Japan, department of social and environmental medicine,osaka university graduate school of medicine,osaka, Japan, department of medical statistics,toho university,tokyo,japan,shiga university of medical science, Japan, department of public health,fujita health university,school of medicine,aichi,japan,fujita health university, Japan, department of public health,shiga university of medical science,shiga,japan,center for epidemiologic research in asia,shiga university of medical science,shiga,japan,toho university, United States, department of public health,shiga university of medical science,shiga,japan,department of epidemiology and public health,kanazawa medical university,ishikawa, Japan, shiga university of medical science,japan,department of public health,shiga university of medical science,shiga,japan,center for epidemiologic research in asia,shiga university of medical science,shiga, Japan, department of preventive medicine and public health,keio university,tokyo,japan,keio university,japan,keio university school of medicine, Japan, tohoku university,graduate school of pharmaceutical sciences, Japan, teikyo university school of medicine, Japan, ibaraki prefecture, Japan, osaka university graduate school of medicine, Japan, kyushu university graduate school of medicine, Japan, kanazawa medical university, Japan, kyoto university school of public health, Japan, research institute of strategy for prevention, Japan, dokkyo medical university, Japan, sapporo medical university, Japan, iwate medical university, United States, hokkaido university graduate school of medicine, Japan, tohoku university graduate school of medicine, Japan, radiation effects research foundation, Japan, osaka center for cancer and cardiovascular disease prevention, Japan, national cerebral and cardiovascular center, Japan, jichi medical university, Japan
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Authors
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