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Effect of a novel stent on re-endothelialization,platelet adhesion,and neointimal formation
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نویسنده
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tang h. ,wang q. ,wang x. ,zhou j. ,zhu m. ,qiao t. ,liu c. ,mao c. ,zhou m.
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منبع
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journal of atherosclerosis and thrombosis - 2016 - دوره : 23 - شماره : 1 - صفحه:67 -80
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چکیده
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Aim: vascular endothelial-cadherin (ve-cadherin. is specifically expressed by outgrowth endothelial cells (oecs) zwitterionic stent showed high antifouling and excellent blood compatibility. therefore,we hypothesized that anti-ve-cadherin antibody-coated zwitterionic stents (ve-cad-z stents) would promote re-endothelialization,reduce neointimal formation,and resist thrombus. methods: ve-cad-z stents were examined using platelet adhesion test,platelet activation,and oec capture ability in vitro. in vivo effect of ve-cad-z stents on re-endothelialization,thrombus-resistance,and neointima hyperplasia was investigated in left common carotid arteries of rabbits (n = 15). results: in vitro,ve-cad-z stents showed better platelet-resistance and oec-capture ability (dna concentration: 297.23±22.71 versus 67.49±15.26 ng/μl,p<0.01. in vivo,ve-cad-z stents exhibited better patency rate than bare metal stents (bms. (15/15 versus 12/15),and it significantly reduced platelet adhesion and neointima formation (neointima area: 1.13±0.05 versus 1.00±0.05 mm2,p<0.01 and 3.04±0.11 ver±1.05±0.06 mm2,p<0.01,at 3 and 30 days,respectively; % stenosis: 20.99±0.98 versus 18.72±0.97,p<0.01 and 56.46±2.20 versus 19.45±1.24,p<0.01,at 3 and 30 days,respectively.. conclusion: these data suggested that ve-cad-z stents could specifically capture oecs,consequently promote endothelial healing,and also reduce platelet adhesion and neointima formation. © 2016,japan atherosclerosis society. all rights reserved.
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کلیدواژه
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Re-endothelialization; Restenosis; Small diameter stent; Vascular endothelial-cadherin; Zwitterionic structures
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آدرس
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department of vascular surgery,nanjing drum tower hospital,the affiliated hospital of nanjing university medical school,nanjing, China, department of vascular surgery,nanjing drum tower hospital,the affiliated hospital of nanjing university medical school,nanjing, China, college of chemistry and materials science,nanjing normal university,nanjing, China, department of general surgery,yixing people’s hospital,yixing, China, department of oral sciences,institute and hospital of stomatology,nanjing university medical school,nanjing, China, department of vascular surgery,nanjing drum tower hospital,the affiliated hospital of nanjing university medical school,nanjing, China, department of vascular surgery,nanjing drum tower hospital,the affiliated hospital of nanjing university medical school,nanjing, China, college of chemistry and materials science,nanjing normal university,nanjing, China, department of vascular surgery,nanjing drum tower hospital,the affiliated hospital of nanjing university medical school,nanjing, China
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Authors
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