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CDH13 polymorphisms are associated with adiponectin levels and metabolic syndrome traits independently of visceral fat mass
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نویسنده
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kitamoto a. ,kitamoto t. ,nakamura t. ,matsuo t. ,nakata y. ,hyogo h. ,ochi h. ,kamohara s. ,miyatake n. ,kotani k. ,mineo i. ,wada j. ,ogawa y. ,yoneda m. ,nakajima a. ,funahashi t. ,miyazaki s. ,tokunaga k. ,masuzaki h. ,ueno t. ,chayama k. ,hamaguchi k. ,yamada k. ,hanafusa t. ,oikawa s. ,sakata t. ,tanaka k. ,matsuzawa y. ,hotta k.
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منبع
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journal of atherosclerosis and thrombosis - 2016 - دوره : 23 - شماره : 3 - صفحه:309 -319
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چکیده
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Aim: visceral fat accumulation contributes to the development of metabolic syndrome. as visceral fat accumulation increases,adiponectin levels decrease; therefore,adiponectin provides a link between visceral fat accumulation and metabolic disorders. genome-wide association studies (gwass) have identified genetic variations in the cadherin 13 (cdh13) gene that are associated with adiponectin levels. methods: we investigated whether single nucleotide polymorphisms (snps) in cdh13 was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (vfa),as measured using computed tomography (ct) in 945 japanese individuals. results: we found that three cdh13 snps reported by recent gwass (i.e.,rs3865188,rs4783244,and rs12051272) were significantly associated with higher adiponectin levels (p<1×10-14),even after adjustment for vfa. however,these adiponectin-inducing alleles of cdh13 snps were significantly associated with traits consistent with deteriorating metabolic symptoms,such as higher fasting insulin,homeostasis model assessment–insulin resistance (homa-ir) scores,and triglycerides and lower highdensity lipoprotein (hdl)-cholesterol levels,similar to increasing vfa and decreasing adiponectin levels. conclusion: these results suggested that cdh13 snps cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits. © 2016,japan atherosclerosis society. all rights reserved.
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آدرس
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pharmacogenomics,kyoto university graduate school of medicine,kyoto, Japan, pharmacogenomics,kyoto university graduate school of medicine,kyoto, Japan, laboratory for mathematics,national defense medical college,tokorozawa, Japan, graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, department of gastroenterology and hepatology,ja hiroshima general hospital,hiroshima, Japan, department of gastroenterology and metabolism,institute of biomedical and health sciences,hiroshima university,hiroshima, Japan, health science university,yamanashi, Japan, department of hygiene,kagawa university,kagawa, Japan, department of metabolic medicine,graduate school of medicine,osaka university,suita, Japan, otemae hospital,osaka, Japan, department of medicine and clinical science,okayama university graduate school of medicine,dentistry and pharmaceutical sciences,okayama, Japan, department of gastroenterology and hepatology,yokohama city university school of medicine,yokohama, Japan, department of gastroenterology and hepatology,yokohama city university school of medicine,yokohama, Japan, department of gastroenterology and hepatology,yokohama city university school of medicine,yokohama, Japan, department of metabolism and atherosclerosis,graduate school of medicine,osaka university,suita, Japan, tokyo postal services agency hospital,tokyo, Japan, itami city hospital,itami, Japan, division of endocrinology,diabetes and metabolism,hematology,rheumatology,graduate school of medicine,university of the ryukyus,okinawa, Japan, research center for innovative cancer therapy,kurume university,kurume, Japan, department of gastroenterology and metabolism,institute of biomedical and health sciences,hiroshima university,hiroshima, Japan, department of practical nursing science,oita university,oita, Japan, division of endocrinology and metabolism,department of medicine,kurume university,kurume, Japan, department of internal medicine (i),osaka medical college,takatsuki, Japan, diabetes and lifestyle disease center,fukujuji hospital,tokyo, Japan, department of internal medicine 1,oita university,oita, Japan, graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, department of metabolic medicine,graduate school of medicine,osaka university,suita, Japan, department of medical innovation,osaka university hospital,suita, Japan
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Authors
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