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   Association between serum elaidic acid concentration and insulin resistance in two Japanese cohorts with different lifestyles  
   
نویسنده itcho k. ,yoshii y. ,ohno h. ,oki k. ,shinohara m. ,irino y. ,toh r. ,ishida t. ,hirata k.-i. ,yoneda m.
منبع journal of atherosclerosis and thrombosis - 2017 - دوره : 24 - شماره : 12 - صفحه:1206 -1214
چکیده    Aim: many cohort studies have shown that increased trans fatty acid (tfa) intake increases the risk of developing coronary heart disease. however,whether tfa intake is directly associated with the development of diabetes mellitus (dm) remains unknown. methods: we performed the 75-g oral glucose tolerance test in two japanese cohorts: a cohort of 454 native japanese living in hiroshima,japan,and a cohort of 426 japanese-americans living in los angeles,usa,who shared identical genetic predispositions but had different lifestyles. serum elaidic acid concentration was measured and compared,and its association with insulin resistance was assessed. results: serum elaidic acid concentrations were significantly higher in the japanese-americans (median,18.2 µmol/l) than in the native japanese (median,11.0 µmol/l). the serum elaidic acid concentrations in the native japanese dm group (16.0 µmol/l) were significantly higher compared with those in the normal glucose tolerance (10.8 µmol/l) and impaired glucose tolerance (11.7 µmol/l) groups. multiple linear regression analyses showed that serum elaidic acid concentrations were significantly positively associated with homeostasis model assessment for insulin resistance (homa-ir) values after adjusting for various factors. conclusions: these results suggest that excessive tfa intake worsens insulin resistance and increases the risk of developing dm even in the native japanese,whose intakes of animal fat and simple carbohydrates were presumed to be lower than those of the japanese-americans. © japan atherosclerosis society.
کلیدواژه Diabetes mellitus; Elaidic acid; Insulin resistance; Trans fatty acid
آدرس department of molecular and internal medicine,graduate school of biomedical and health sciences,hiroshima university,hiroshima, Japan, department of molecular and internal medicine,graduate school of biomedical and health sciences,hiroshima university,hiroshima, Japan, department of molecular and internal medicine,graduate school of biomedical and health sciences,hiroshima university,hiroshima, Japan, department of molecular and internal medicine,graduate school of biomedical and health sciences,hiroshima university,hiroshima, Japan, division of cardiovascular medicine,department of internal medicine,kobe university graduate school of medicine,kobe, Japan, division of evidence-based laboratory medicine,kobe university graduate school of medicine,kobe, Japan, division of evidence-based laboratory medicine,kobe university graduate school of medicine,kobe, Japan, division of cardiovascular medicine,department of internal medicine,kobe university graduate school of medicine,kobe, Japan, division of cardiovascular medicine,department of internal medicine,kobe university graduate school of medicine,kobe, Japan, department of molecular and internal medicine,graduate school of biomedical and health sciences,hiroshima university,hiroshima, Japan
 
     
   
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