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Genetic variants of RAMP2 and CLR are associated with stroke
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نویسنده
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koyama t. ,kuriyama n. ,ozaki e. ,matsui d. ,watanabe i. ,takeshita w. ,iwai k. ,watanabe y. ,nakatochi m. ,shimanoe c. ,tanaka k. ,oze i. ,ito h. ,uemura h. ,katsuura-kamano s. ,ibusuki r. ,shimoshikiryo i. ,takashima n. ,kadota a. ,kawai s. ,sasakabe t. ,okada r. ,hishida a. ,naito m. ,kuriki k. ,endoh k. ,furusyo n. ,ikezaki h. ,suzuki s. ,hosono a. ,mikami h. ,nakamura y. ,kubo m. ,wakai k.
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منبع
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journal of atherosclerosis and thrombosis - 2017 - دوره : 24 - شماره : 12 - صفحه:1267 -1281
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چکیده
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Aim: stroke is associated closely with vascular homeostasis,and several complex processes and interacting pathways,which involve various genetic and environmental factors,contribute to the risk of stroke. although adrenomedullin (adm) has a number of physiological and vasoprotective functions,there are few studies of the adm receptor system in humans. the adm receptor comprises a calcitonin-receptor-like receptor (clr) and receptor activity-modifying proteins (ramps). we analyzed single nucleotide polymorphisms (snps) in the ramp2 and clr genes to determine their association with stroke in the light of gene-environment interactions. methods: using cross-sectional data from the japan multi-institutional collaborative cohort study in the baseline surveys,14,087 participants from 12 research areas were genotyped. we conducted a hypothesis-based association between stroke prevalence and snps in the ramp2 and clr genes based on data abstracted from two snps in ramp2 and 369 snps in clr. we selected five snps from among the clr variants (rs77035639,rs3815524,rs75380157,rs574603859,and rs147565266) and one ramp2 snp (rs753152),which were associated with stroke,for analysis. results: five of the snps (rs77035639,rs3815524,rs75380157,rs147565266,and rs753152) showed no significant association with obesity,ischemic heart disease,hypertension,dyslipidemia,and diabetes. in the logistic regression analysis,rs574603859 had a lower odds ratio (0.238; 95% confidence interval,0.076-0.745,adjusted for age,sex,and research area) and the other snps had higher odds ratios for association with stroke. conclusions: this was the first study to investigate the relationships between adm receptor genes (ramp2 and clr) and stroke in the light of gene-environment interactions in human. © japan atherosclerosis society.
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کلیدواژه
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Adrenomedullin; Calcitonin-receptor-like receptor; Receptor activity-modifying protein 2; Stroke
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آدرس
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department of epidemiology for community health and medicine,kyoto prefectural university of medicine,kyoto, Japan, department of epidemiology for community health and medicine,kyoto prefectural university of medicine,kyoto, Japan, department of epidemiology for community health and medicine,kyoto prefectural university of medicine,kyoto, Japan, department of epidemiology for community health and medicine,kyoto prefectural university of medicine,kyoto, Japan, department of epidemiology for community health and medicine,kyoto prefectural university of medicine,kyoto, Japan, department of epidemiology for community health and medicine,kyoto prefectural university of medicine,kyoto, Japan, department of epidemiology for community health and medicine,kyoto prefectural university of medicine,kyoto, Japan, department of epidemiology for community health and medicine,kyoto prefectural university of medicine,kyoto, Japan, center for advanced medicine and clinical research,nagoya university hospital,nagoya, Japan, department of preventive medicine,faculty of medicine,saga university,saga, Japan, department of preventive medicine,faculty of medicine,saga university,saga, Japan, division of molecular and clinical epidemiology,aichi cancer center research institute,nagoya, Japan, division of molecular and clinical epidemiology,aichi cancer center research institute,nagoya, Japan, department of preventive medicine,institute of biomedical sciences,tokushima university graduate school,tokushima, Japan, department of preventive medicine,institute of biomedical sciences,tokushima university graduate school,tokushima, Japan, department of international islands and community medicine,kagoshima university graduate school of medical and dental sciences,kagoshima, Japan, department of international islands and community medicine,kagoshima university graduate school of medical and dental sciences,kagoshima, Japan, department of public health,shiga university of medical scienceshiga, Japan, department of public health,shiga university of medical scienceshiga,japan,center for epidemiologic research in asia,shiga university of medical scienceshiga, Japan, department of preventive medicine,nagoya university graduate school of medicine,nagoya, Japan, department of preventive medicine,nagoya university graduate school of medicine,nagoya, Japan, department of preventive medicine,nagoya university graduate school of medicine,nagoya, Japan, department of preventive medicine,nagoya university graduate school of medicine,nagoya, Japan, department of preventive medicine,nagoya university graduate school of medicine,nagoya, Japan, laboratory of public health,school of food and nutritional sciences,university of shizuoka,shizuoka, Japan, laboratory of public health,school of food and nutritional sciences,university of shizuoka,shizuoka, Japan, department of environmental medicine and infectious disease,kyushu university,fukuoka, Japan, department of environmental medicine and infectious disease,kyushu university,fukuoka, Japan, department of public health,nagoya city university graduate school of medical sciences,nagoya, Japan, department of public health,nagoya city university graduate school of medical sciences,nagoya, Japan, cancer prevention center,chiba cancer center research institute,chiba, Japan, cancer prevention center,chiba cancer center research institute,chiba, Japan, laboratory for genotyping development,center for integrative medical sciences,riken,yokohama, Japan, department of preventive medicine,nagoya university graduate school of medicine,nagoya, Japan
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Authors
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