The relation between serum endostatin level and carotid atherosclerosis in healthy residents of Japan: Results from the kyushu and okinawa population study (KOPS)

Aim: to examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy japanese population. methods: among 1,057 residents who attended free public physical examinations between 2010 and 2011,we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (imt) were successfully measured. results: the median endostatin level was 63.7 ng/ml (interquartile ranges: 49.7.93.2 ng/ml),and the mean carotid imt was 0.68±0.12 mm. residents with above median endostatin had significantly higher carotid imt than did those with below median endostatin (0.71±0.14 vs. 0.65±0.09 mm,p<0.001). multiple linear regression analysis demonstrated that increased serum endostatin is significantly associated with carotid imt (above vs. below median endostatin level; beta = 0.11,p = 0.03),independent of the known covariates of age,sex,body mass index,drinking and smoking status,systolic blood pressure,diastolic blood pressure,hemoglobin a1c,low density lipoprotein cholesterol,estimated glomerular filtration rate,and log-transformed high sensitive c-reactive protein. conclusions: a higher serum endostatin level reflected subclinical atherosclerosis in this japanese population. © 2017 japan atherosclerosis society.