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   Cardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with Ischemic heart disease  
   
نویسنده miyoshi t. ,doi m. ,hirohata s. ,sakane k. ,kamikawa s. ,kitawaki t. ,kaji y. ,kusano k.f. ,ninomiya y. ,kusachi s.
منبع journal of atherosclerosis and thrombosis - 2010 - دوره : 17 - شماره : 3 - صفحه:249 -258
چکیده    Aim: the cardio-ankle vascular index (cavi) has been proposed as a new noninvasive marker of arterial stiffness independent of blood pressure. we investigated the association of the cavi with coronary atherosclerosis and left ventricular (lv) systolic and diastolic function in patients with ischemic heart disease (ihd). methods: a total of 206 consecutive subjects undergoing coronary angiography were enrolled. cavi measurement and echocardiography were performed simultaneously. patients having significant coronary stenosis were classified into the ihd group. results: cavi in the ihd group (n 133) was significantly higher than in the non-ihd group (n 73) (9.1±1.3 vs. 8.7±1.2,p 0.02). in all ihd patients,cavi was negatively correlated with lv ejection fraction (lvef) (r=-0.31,p<0.01),lv mass index (r 0.24,p<0.01) and angiographic scores of coronary atherosclerosis. stepwise regression analysis revealed that cavi was independently associated with lvef,along with a history of myocardial infarction,lv mass index,and left atrial diameter in all ihd patients (p<0.01). in the sub-analysis of ihd patients with preserved lvef,cavi was correlated with echocardiographic parameters regarding lv diastolic function. multivariate analysis demonstrated that the increased cavi was significantly associated with lv diastolic dysfunction in patients with preserved lvef. conclusion: cavi,a new parameter of aortic stiffness,was independently associated with lv systolic and diastolic function as well as coronary artery disease in ihd patients.
کلیدواژه Arterial stiffness; Cardio-ankle vascular index; Ischemic heart disease; Left ventricular function
آدرس department of molecular biology and biochemistry,okayama university graduate school of medicine,dentistry and pharmaceutical sciences,okayama, Japan, division of cardiology,sumitomo besshi hospital,niihama, Japan, department of molecular biology and biochemistry,okayama university graduate school of medicine,dentistry and pharmaceutical sciences,okayama, Japan, division of cardiology,sumitomo besshi hospital,niihama, Japan, department of molecular biology and biochemistry,okayama university graduate school of medicine,dentistry and pharmaceutical sciences,okayama, Japan, department of medical technology,okayama university graduate school of health sciences,okayama, Japan, division of cardiology,sumitomo besshi hospital,niihama, Japan, department of cardiovascular medicine,okayama university graduate school of medicine,dentistry and pharmaceutical sciences,okayama, Japan, department of molecular biology and biochemistry,okayama university graduate school of medicine,dentistry and pharmaceutical sciences,okayama, Japan, department of medical technology,okayama university graduate school of health sciences,okayama, Japan
 
     
   
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