Effects of supervised aerobic exercise training on serum adiponectin and parameters of lipid and glucose metabolism in subjects with moderate dyslipidemia

Aim: to examine the effects of supervised aerobic exercise training on serum adiponectin and lipids,including triglyceride (tg)-rich lipoproteins,in moderate dyslipidemic subjects. methods: twenty-five dyslipidemic patients [mean body mass index (bmi)=24.6 kg/m2; mean age= 39 years; mean total cholesterol=226 mg/dl; mean tg=149 mg/dl] without metabolic syndrome,diabetes,and hypertension underwent supervised aerobic exercise training (60 min/day,2 to 3 times/week) at an intensity of 60-80% of age-predicted maximal heart rate for 16 weeks. lipoprotein cholesterol levels were measured by our established anion-exchange hplc method. results: aerobic exercise training significantly decreased bmi,cholesterol levels of ldl- and idl-,and markedly reduced vldl-cholesterol at week 8 (-45%) and week 16 (-50%),but changes in tg and hdl-cholesterol were not significant. adiponectin significantly increased by 51% and homa-r was significantly decreased at week 16,although changes in these parameters were not significant at week 8. there was no significant relationship between changes in adiponectin and in vldl- or idl- cholesterol,but changes in adiponectin were inversely but insignificantly associated with changes in bmi (r=-0.343,p=0.095). conclusions: these results suggest that supervised aerobic exercise training two to three times/week in the presence of body weight loss increases serum adiponectin with an improved lipid profile and insulin sensitivity at week 16 in non-obese moderate dyslipidemic patients,and that vldl-cholesterol is markedly decreased by supervised aerobic exercise training.