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Sirt1/eNOS axis as a potential target against vascular senescence,dysfunction and atherosclerosis
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نویسنده
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ota h. ,eto m. ,ogawa s. ,iijima k. ,akishita m. ,ouchi y.
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منبع
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journal of atherosclerosis and thrombosis - 2010 - دوره : 17 - شماره : 5 - صفحه:431 -435
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چکیده
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Sir2 (silent information regulator-2),an nad+-dependent histone deacetylase,is highly conserved in organisms ranging from archaea to humans. yeast sir2 is responsible for silencing at repeated dna sequences in mating-type loci,telomeres and rdna,and plays critical roles in dna repair,stress resistance and longevity. the phenomenon of human aging is known to be a critical cardiovascular risk factor. senescence of endothelial cells has been proposed to be involved in vascular dysfunction and atherogenesis. recent studies have demonstrated that mammalian sirt1 nad+-dependent protein deacetylase,the closest homologue of sir2,regulates vascular angiogenesis,homeostasis and senescence. this review focuses on sirt1 as a potential therapeutic target against atherosclerosis.
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کلیدواژه
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Atherosclerosis; Dysfunction; Sirt1; Vascular senescence
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آدرس
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department of geriatric medicine,graduate school of medicine,university of tokyo,tokyo, Japan, department of geriatric medicine,graduate school of medicine,university of tokyo,tokyo, Japan, department of geriatric medicine,graduate school of medicine,university of tokyo,tokyo, Japan, department of geriatric medicine,graduate school of medicine,university of tokyo,tokyo, Japan, department of geriatric medicine,graduate school of medicine,university of tokyo,tokyo, Japan, department of geriatric medicine,graduate school of medicine,university of tokyo,tokyo, Japan
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Authors
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