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Chlamydia pneumoniae infection was associated with risk of mortality from coronary heart disease in Japanese women but not men: the JACC study
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نویسنده
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sakurai-komada n. ,koike k.a. ,kaku y. ,hiraki m. ,cui r. ,sankai t. ,kikuchi s. ,date c. ,tamakoshi a. ,iso h.
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منبع
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journal of atherosclerosis and thrombosis - 2010 - دوره : 17 - شماره : 5 - صفحه:510 -516
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چکیده
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Aim: to investigate the association between chlamydiapneumoniae infection and mortality from coronary heart disease,a nested case-control study was conducted for 39,242 japanese who participated in the jacc study. methods: immunoglobulin a and g titers of c. pneumoniae were measured in stored serum samples collected from 209 patients (113 men and 96 women) who subsequently died of coronary heart dis-ease after 13-year follow-up; and 209 controls matched for gender,age (±5 years) and area of resi-dence. results: after adjustment for high-sensitive crp and other cardiovascular risk factors,the multivari-ate odds ratio (or) of coronary heart disease for highest vs. lowest tertiles of iga titers was 2.69 (95%ci,1.00-7.20),p 0.049 for women and 0.58 (0.23-1.46),p0.25 for men (p for interac-tion0.03). a similar association was observed by high (++) vs. low (-/±) titers of iga: multivariate or was 4.09 (0.86-19.4),p0.07 for women.conclusions: since high iga titers indicate persistent and repeated infection,such a state is associated with an increased risk of coronary heart disease mortality for women.
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کلیدواژه
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Chlamydia pneumoniae; Coronary heart disease; Jacc study; Risk factor
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آدرس
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center for medical sciences,school of health sciences,ibaraki prefectural university of health sciences,ibaraki, Japan, center for medical sciences,school of health sciences,ibaraki prefectural university of health sciences,ibaraki,japan,school of health sciences,uekusagakuen university,chiba, Japan, department of public health medicine,graduate school of comprehensive human science,and institute of community medicine,university of tsukuba,ibaraki, Japan, center for medical sciences,school of health sciences,ibaraki prefectural university of health sciences,ibaraki, Japan, department of social and environmental medicine,osaka university graduate school of medicine,osaka, Japan, industrial safety and health dept.,canon inc. tride plant,ibaraki, Japan, department of public health,aichi medical university,school of medicine,aichi, Japan, department of food science and nutrition,faculty of human life and environment,nara women's university,nara, Japan, division of clinical trial,national center for geriatrics and gerontology,nagoya, Japan, department of social and environmental medicine,osaka university graduate school of medicine,osaka, Japan
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Authors
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