Plasma level of platelet-derived microparticles is associated with coronary heart disease risk score in healthy men

Aim: the aim of this study was to clarify the relationship between platelet-derived microparticles (pdmps) and the framingham 10-yr coronary heart disease (chd) risk score. methods: a cross-sectional study of healthy volunteers free of medication,and cardiovascular or cere- brovascular disease was conducted. the subjects were 190 japanese men (median age 41). an elisa kit and monoclonal antibodies against cd42b and cd42a (glycoprotein ib and ix) were used. results: pdmps are correlated with platelet count,high sensitivity c-reactive protein (hscrp),and diastolic blood pressure by multivariate analysis (r2=0.316,p-0.001). quartile range of pdmps is significantly associated with the 10-yr chd risk score after adjusting for age,platelet count,hscrp,and hypertension (p 0.033) and for age,platelet count,hscrp,and presence of metabolic syndrome (ms) (p=0.020). in individuals with a predicted 10-yr risk for chd ≥8% (corresponding with the highest quartile),compared to those with a predicted 10-yr risk <8%,the odds ratio (or),adjusted for age,platelet count,hscrp,and hypertension,was 3.3 (1.2 - 8.9) and adjusted for age,platelet count,hscrp,and ms,was 4.5 (1.6 - 11.8). the age-,platelet count-,hscrp- and hypertensionadjusted or for a 10-yr chd risk score ≥8% was 0.8 (0.5 - 1.3) for hscrp and 3.9 (1.6 - 9.4) for hypertension. the age-,platelet count-,hscrp- and ms -adjusted or for a 10-yr chd risk score ≥8% was 0.7 (0.4 - 1.2) for hscrp and 7.9 (2.6 - 24.5) for ms. conclusion: elevated pdmps are associated with the 10-yr chd risk score in healthy men.