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   Plasma level of platelet-derived microparticles is associated with coronary heart disease risk score in healthy men  
   
نویسنده ueba t. ,nomura s. ,inami n. ,nishikawa t. ,kajiwara m. ,iwata r. ,yamashita k.
منبع journal of atherosclerosis and thrombosis - 2010 - دوره : 17 - شماره : 4 - صفحه:342 -349
چکیده    Aim: the aim of this study was to clarify the relationship between platelet-derived microparticles (pdmps) and the framingham 10-yr coronary heart disease (chd) risk score. methods: a cross-sectional study of healthy volunteers free of medication,and cardiovascular or cere- brovascular disease was conducted. the subjects were 190 japanese men (median age 41). an elisa kit and monoclonal antibodies against cd42b and cd42a (glycoprotein ib and ix) were used. results: pdmps are correlated with platelet count,high sensitivity c-reactive protein (hscrp),and diastolic blood pressure by multivariate analysis (r2=0.316,p-0.001). quartile range of pdmps is significantly associated with the 10-yr chd risk score after adjusting for age,platelet count,hscrp,and hypertension (p 0.033) and for age,platelet count,hscrp,and presence of metabolic syndrome (ms) (p=0.020). in individuals with a predicted 10-yr risk for chd ≥8% (corresponding with the highest quartile),compared to those with a predicted 10-yr risk <8%,the odds ratio (or),adjusted for age,platelet count,hscrp,and hypertension,was 3.3 (1.2 - 8.9) and adjusted for age,platelet count,hscrp,and ms,was 4.5 (1.6 - 11.8). the age-,platelet count-,hscrp- and hypertensionadjusted or for a 10-yr chd risk score ≥8% was 0.8 (0.5 - 1.3) for hscrp and 3.9 (1.6 - 9.4) for hypertension. the age-,platelet count-,hscrp- and ms -adjusted or for a 10-yr chd risk score ≥8% was 0.7 (0.4 - 1.2) for hscrp and 7.9 (2.6 - 24.5) for ms. conclusion: elevated pdmps are associated with the 10-yr chd risk score in healthy men.
کلیدواژه Atherothrombosis; Framingham coronary heart disease risk score; High sensitivity CRP; Platelet-derived microparticle
آدرس department of neurosurgery,kishiwada city hospital,osaka, Japan, department of hematology,kishiwada city hospital,osaka, Japan, 2nd department of internal medicine,kansai medical university,osaka, Japan, department of neurosurgery,kishiwada city hospital,osaka, Japan, department of neurosurgery,kishiwada city hospital,osaka, Japan, department of neurosurgery,kishiwada city hospital,osaka, Japan, department of neurosurgery,kishiwada city hospital,osaka, Japan
 
     
   
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