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Effect of ezetimibe monotherapy on lipid metabolism and arterial stiffness assessed by cardio-ankle vascular index in type 2 diabetic patients
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نویسنده
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miyashita y. ,endo k. ,saiki a. ,ban n. ,nagumo a. ,yamaguchi t. ,kawana h. ,nagayama d. ,ohira m. ,oyama t. ,shirai k.
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منبع
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journal of atherosclerosis and thrombosis - 2010 - دوره : 17 - شماره : 10 - صفحه:1070 -1076
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چکیده
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Aim: high cholesterol absorption in the small intestine has been proposed to be a risk factor of atherosclerosis. in this study,we evaluated the effect of ezetimibe monotherapy on arterial stiffness in type 2 diabetic patients. methods: forty type 2 diabetes mellitus patients with high serum low-density lipoprotein cholesterol (ldl-c) were enrolled and treated with ezetimibe 10 mg/day for 6 months. hba1c,serum lipids,remnant-like particle-cholesterol (rlp-c),serum lipoprotein lipase mass (lpl mass) and the cardioankle vascular index (cavi) were measured before and after ezetimibe treatment. results: after 6 months of ezetimibe treatment,significant decreases in ldl-c,rlp-c and cavi were observed. in the group that achieved the ldl-c goal of <120 mg/dl after 6 months of ezetimibe treatment,the pretreatment cavi was markedly high,and cavi decreased significantly after ezetimibe treatment. conclusions: in type 2 diabetic patients,ezetimibe monotherapy may have the potential to ameliorate arterial stiffness in addition to lowering ldl-c and rlp-c.
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کلیدواژه
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Cardio-ankle vascular index; Ezetimibe; Remnant like particle
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آدرس
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departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan, departments of internal medicine,sakura medical center,school of medicine,toho university,chiba, Japan
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Authors
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