Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects

Aim: helicobacter pylori infection was associated with the risk of cardiovascular disease; however,the relation between helicobacter pylori infection and the lipid profile has not been fully established. methods: we measured anti-helicobacter pylori antibody concentration and lipid profiles in 6,289 japanese subjects aged 21-64 years (5,077 male and 1,212 female). results: the prevalence of helicobacter pylori-seropositive subjects was 46.8% and 39.6% in men and women,respectively. adjusted mean values of low-density lipoprotein (ldl) cholesterol and high-density lipoprotein (hdl) cholesterol in men were significantly higher and lower in helicobacter pylori-seropositive than-negative subjects,respectively,(ldl-cholesterol: 129.0±0.8 vs. 125.3 ±0.7 mg/dl,p<0.001,hdl-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dl,p<0.01),whereas these associations were not significant in female subjects. moreover,the odds ratio of helicobacter pylori infection for high ldl-cholesteremia and low hdl-cholesteremia in male subjects was 1.23 (95% ci (confidence interval): 1.08-1.40,p<0.05) and 1.29 (95% ci: 1.03-1.59,p<0.05),respectively. female subjects did not have such associations. conclusions: the present study demonstrates that helicobacter pylori infection is significantly associated with high ldl-cholesteremia and low hdl-cholesteremia in japanese male subjects.