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   Effects of low-dose simvastatin on the distribution of plasma cholesterol and oxidized low-density lipoprotein in three ultracentrifugally separated low-density lipoprotein subfractions: 12-month,open-label trial  
   
نویسنده homma y. ,michishita i. ,hayashi h. ,shigematsu h.
منبع journal of atherosclerosis and thrombosis - 2010 - دوره : 17 - شماره : 10 - صفحه:1049 -1053
چکیده    Aim: the effects of statins on the distribution of oxidized ldl in plasma ldl subfractions have not been well defined. effects of 12-month treatment with low-dose simvastatin on the distribution of cholesterol and oxidized ldl in 3 ultracentrifugally separated plasma ldl subfractions were compared in patients with hypercholesterolemia. methods: simvastain was administered to 30 hypercholesterolemic subjects for 12 months at an initial dose of 5 mg/day,which was increased to 20 mg/day via 10mg/day to decrease plasma ldl- cholesterol (c) lower than 130 mg/dl. simvastatin dose was fixed after 3 months of treatment. the amounts of cholesterol and oxidized ldl in 3 ultracentrifugally separated plasma ldl subfractions were compared between 0 and 12 months of treatment. results: the distribution of ox-ldl skewed to denser ldl fractions,compared with cholesterol in plasma ldl subfractions. plasma cholesterol in low-density ldl,medium-density ldl and highdensity ldl decreased significantly by 31%,30%,and 25%,respectively (p<0.0001) after 12 months of simvastatin treatment. plasma oxidized ldl was decreased from 70 u/l to 56 u/l in medium-density ldl (p = 0.042). oxidized ldl in low-density ldl and high-density ldl did not change significantly after 12 months of treatment. conclusion: treatment with low-dose simvastatin decreased plasma cholesterol in 3 ldl subfractions and oxidized ldl in medium-density ldl. the decrease of oxidized ldl seemed to be not due to the decrease of cholesterol in plasma ldl subfractions because the decreasing patterns of cholesterol and ox-ldl were different in 3 ldl subfractions.
کلیدواژه Hs-CRP; LDL subfractions; Ox-LDL; Plasma lipids; Plasma lipoprotein subfractions; Simvastatin
آدرس health evaluation and promotion center,tokai university hospital,isehara, Japan, department of cardiology,yokohama sakae municipal hospital,yokohama, Japan, department of internal medicine,atami hospital,international university of health and welfare,atami, Japan, sato internal medical clinic,yokohama, Japan
 
     
   
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