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Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population
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نویسنده
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koriyama h. ,nakagami h. ,katsuya t. ,sugimoto k. ,yamashita h. ,takami y. ,maeda s. ,kubo m. ,takahashi a. ,nakamura y. ,ogihara t. ,rakugi h. ,kaneda y. ,morishita r.
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منبع
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journal of atherosclerosis and thrombosis - 2010 - دوره : 17 - شماره : 10 - صفحه:1054 -1062
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چکیده
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Aim: peripheral arterial disease (pad) is a common cause of cardiovascular morbidity and an independent predictor of cardiovascular mortality. however,little is known about the genetic basis of pad. to elucidate this,we performed a two-staged genome-wide association study in japanese individuals. methods: we initially tested 222,285 single-nucleotide polymorphisms (snps). after the first screening in a panel of 195 pad cases and 1,358 controls,2,696 snps (1.2%) were further genotyped in the second screening using another panel of 699 pad cases and 1540 controls. in both screenings,controls were subjects affected with some diseases other than pad. results: when analyzed in the combined panel,the strongest signal of pad association was observed at rs1902341 in the intron of osbpl10 (p = 4.7e-7 for trend test; or = 1.31,95% ci 1.18-1.46). also,pad was modestly associated at several other loci such as rs2554503 in csmd1 (p = 5.7e-5; or = 1.32,95% ci 1.15-1.51) or rs235243 in vsp13d (p = 0.04; or = 1.18,95% ci 1.01-1.37). conclusion: our genome-wide exploration identified suggestive evidence of pad association at the osbpl10 locus. because the association has not reached a genome-wide significant level,further replication study is warranted for verification in the japanese population.
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کلیدواژه
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Genome-wide association study; OSBPL10; Peripheral arterial disease
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آدرس
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department of geriatric medicine and nephrology,osaka university graduate school of medicine,suita, Japan, division of gene therapy science,osaka university graduate school of medicine,suita, Japan, department of geriatric medicine and nephrology,osaka university graduate school of medicine,suita,japan,division of clinical gene therapy,osaka university graduate school of medicine,suita, Japan, department of geriatric medicine and nephrology,osaka university graduate school of medicine,suita, Japan, division of gene therapy science,osaka university graduate school of medicine,suita, Japan, department of geriatric medicine and nephrology,osaka university graduate school of medicine,suita, Japan, laboratory for endocrinology and metabolism,center for genomic medicine,riken,tokyo, Japan, laboratory for genotyping development,center for genomic medicine,riken,yokohama, Japan, laboratory for statistical analysis,center for genomic medicine,riken,tokyo, Japan, laboratory of molecular medicine,human genome center,institute of medical science,university of tokyo,tokyo, Japan, osaka general medical center,osaka prefectural hospital organization,osaka, Japan, department of geriatric medicine and nephrology,osaka university graduate school of medicine,suita, Japan, division of gene therapy science,osaka university graduate school of medicine,suita, Japan, division of clinical gene therapy,osaka university graduate school of medicine,suita, Japan
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Authors
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