Insulin resistance and prevalence of prehypertension and hypertension among community-dwelling persons

Aim: there are few data focusing on the effect of insulin resistance on a new risk category of prehypertension (120-139 mmhg systolic and/or 80-89 mmhg diastolic blood pressure) recently established by the seventh report of the joint national committee on high blood pressure (jnc-7). we aimed to determine whether insulin resistance was associated with a risk for prehypertension and hypertension. methods: of 3,164 (34.6% of 9,133 adults aged 19 to 90 years) adults at the community-based annual medical check-up,study participants without a clinical history of stroke,transient ischemic attack,myocardial infarction,angina,or renal failure (567 men aged 57 ± 14 (mean ± standard deviation); range,20-84) years and 702 women aged 59 ± 12; 21-88 years) were recruited. we examined the cross-sectional relationship between insulin resistance,which was evaluated by homeostasis of minimal assessment of insulin resistance (homa-ir) and normotension,prehypertension,or hypertension using the jnc-7 criteria. results: the homa-ir correlated significantly with systolic (r = 0.171) and diastolic (r = 0.170) blood pressures. triglycerides ≥ 150 mg/dl,hdl-c <40 mg/dl,metabolic syndrome,serum uric acid ≥ 7.0 mg/dl,and homa-ir ≥ 2.5 showed the highest crude odds ratio (or) for progression from normotension to prehypertension,and ≥ 65 years,fbg ≥ 110 mg/dl,metabolic syndrome,and homa-ir ≥ 2.5 showed the highest crude or for progression from normotension to hypertension. multivariate logistic regression analysis showed that homa-ir was independently associated with the presence of prehypertension and hypertension. conclusions: insulin resistance was significantly associated with prehypertension as well as hypertension in the general population.