HSG/Mfn2 gene polymorphism and essential hypertension: A case-control association study in Chinese

Aim: hyperplasia suppressor gene/mitofusion-2 (hsg/mfn2) is a hyperplasia suppressor gene and an essential component of mitochondrial fusion machinery; however,the association between the single nucleotide polymorphism (snp) of hsg/mfn2 and hypertension is unclear. methods: in this study,542 normotensive subjects (nt group) and 539 hypertensive patients (eh group) were screened for an association study between hsg/mfn2 and hypertension. results: the results showed that the genotype distribution and allelic frequency of rs873457,rs2336384,rs1474868,rs4846085 and rs2236055 were significantly different (p<0.05 for all) between eh and nt groups,although those of rs4240897 and rs873458 were not. when comparing the dominant model,significant differences still existed (p<0.05 for all). the allelic frequency of rs4240897 was also slightly different between eh and nt groups (p = 0.047). when subgrouped by sex,the genotype distribution and allelic frequency of all the snps (except rs873458) were significantly different in male (p<0.05 for all) but not in female groups. for all the snps,only the allelic frequency of rs4240897 was obviously different in female nt and eh groups (p<0.01). logistic regression showed that body mass index and rs873457 were closely associated with bp after adjusting for age. the frequency of the c-g-a-a-a-c-c haplotype was significantly higher in essential hypertensive patients versus control individuals,both in the entire population,in male or female groups (p<0.01 for all). as for other haplotypes,most were only significantly different in the entire population and male subjects. conclusion: the genetic variations of hsg/mfn2 may be associated with hypertension in male chinese.