Relationship between two AMI risk factors: Low serum lipoprotein lipase mass and hypoadiponectinemia

Aim: recent clinical studies have reported that low lipoprotein lipase mass in preheparin serum (s-lpl) and hypoadiponectinemia are important risk factors for acute myocardial infarction (ami). the aim of this study was to elucidate the relationship between low s-lpl and hypoadiponectinemia,both of which are risk factors for ami. methods: one hundred and thirty-seven male patients with ami and fifty-three males with normal coronary arteries (nca) were enrolled in the study. coronary risk factors,including s-lpl and serum total adiponectin concentrations (t-adiponectin),were compared. results: both s-lpl and t-adiponectin were significantly lower in patients with ami than in subjects with nca (s-lpl,nca: 48.1±11.0 ng/ml,ami: 38.9±11.1 ng/ml,p<0.01; t-adiponectin,nca: 7.7±2.9 μg/ml,ami: 6.1±3.3 μg/ml,p<0.01). in ami patients,there was a significant positive correlation between s-lpl and t-adiponectin (r = 0.46,p<0.01). furthermore,multivariate analysis indicated that both s-lpl and t-adiponectin were independent variables for ami (s-lpl: p< 0.05,t-adiponectin: p<0.05). conclusion: these results indicate that although low s-lpl and hypoadiponectinemia are associated with each other,they are independent risk factors for ami.