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Elevated antibody titers to porphyromonas gingivalis as a possible predictor of ischemic vascular disease: Results from the tokamachi-nakasato cohort study
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نویسنده
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tabeta k. ,tanabe n. ,yonezawa d. ,miyashita h. ,maekawa t. ,takahashi n. ,okui t. ,nakajima t. ,yamazaki k.
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منبع
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journal of atherosclerosis and thrombosis - 2011 - دوره : 18 - شماره : 9 - صفحه:808 -817
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چکیده
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Aim: limited epidemiological studies have investigated the relationship between ischemic vascular disease and periodontitis in non-western populations. we investigated this relationship in a japanese cohort by measuring serum titers of antibodies to periodontopathic bacteria. methods: as part of the tokamachi-nakasato cohort study,we followed up 7021 participants regarding cardiovascular events over 5 years,and observed 99 ischemic vascular events: 66 cerebral infarctions and 33 cases of ischemic heart disease (ihd). for a nested case-control study,we selected 495 sex- and age-matched control subjects. conditional logistic regression analysis was used to estimate the odds ratios (or) and 95% confidence intervals (ci) of ischemic vascular events associated with antibody titers to porphyromonas gingivalis fdc381 and su63. multivariable models were adjusted for traditional cardiovascular risk factors using propensity scores. results: the highest tertile category of antibody titers to p. gingivalis fdc381 in men was significantly associated with an increased risk of cerebral infarction in only the crude model. the 2nd and 3rd tertile categories of antibody titers to p. gingivalis su63 were significantly associated with an increased risk of cerebral infarction in men (multivariable ors (95% cis) were 7.12 (1.51-33.5) and 9.03 (1.97-41.5),respectively). the association was not appreciably modified when we further adjusted for serum high-sensitivity c-reactive protein levels. antibody titers to p. gingivalis were not dose-dependently associated with the risk of ihd. conclusion: high serum antibody titers to p. gingivalis su63 could be a predictor of cerebral infarction in japanese men independent of traditional risk factors and inflammation.
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کلیدواژه
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Cerebral infarction; Ischemic heart disease; Periodontitis; Porphyromonas gingivalis; Serum antibody
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آدرس
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center for transdisciplinary research,niigata university,niigata, Japan, division of health promotion,niigata university graduate school of medical and dental sciences,niigata, Japan, laboratory of periodontology and immunology,department of oral health and welfare,faculty of dentistry,niigata university,5274 gakkocho 2-ban-cho,niigata 951-8514, Japan, center for transdisciplinary research,niigata university,niigata,japan,laboratory of periodontology and immunology,department of oral health and welfare,faculty of dentistry,niigata university,5274 gakkocho 2-ban-cho,niigata 951-8514, Japan, center for transdisciplinary research,niigata university,niigata,japan,laboratory of periodontology and immunology,department of oral health and welfare,faculty of dentistry,niigata university,5274 gakkocho 2-ban-cho,niigata 951-8514, Japan, center for transdisciplinary research,niigata university,niigata,japan,laboratory of periodontology and immunology,department of oral health and welfare,faculty of dentistry,niigata university,5274 gakkocho 2-ban-cho,niigata 951-8514, Japan, center for transdisciplinary research,niigata university,niigata,japan,laboratory of periodontology and immunology,department of oral health and welfare,faculty of dentistry,niigata university,5274 gakkocho 2-ban-cho,niigata 951-8514, Japan, center for transdisciplinary research,niigata university,niigata,japan,general dentistry and clinical education unit,niigata university medical and dental hospital,niigata, Japan, center for transdisciplinary research,niigata university,niigata,japan,laboratory of periodontology and immunology,department of oral health and welfare,faculty of dentistry,niigata university,5274 gakkocho 2-ban-cho,niigata 951-8514, Japan
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