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Diagnosis and management of type I and type V hyperlipoproteinemia
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نویسنده
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gotoda t. ,shirai k. ,ohta t. ,kobayashi j. ,yokoyama s. ,oikawa s. ,bujo h. ,ishibashi s. ,arai h. ,yamashita s. ,harada-shiba m. ,eto m. ,hayashi t. ,sone h. ,suzuki h. ,yamada n.
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منبع
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journal of atherosclerosis and thrombosis - 2012 - دوره : 19 - شماره : 1 - صفحه:1 -12
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چکیده
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Both type i and type v hyperlipoproteinemia are characterized by severe hypertriglyceridemia due to an increase in chylomicrons. type i hyperlipoproteinemia is caused by a decisive abnormality of the lipoprotein lipase (lpl)-apolipoprotein c-ii system,whereas the cause of type i v hyperlipoproteinemia is more complicated and more closely related to acquired environmental factors. since the relationship of hypertriglyceridemia with atherosclerosis is not as clear as that of hypercholesterolemia,and since type i and v hyperlipoproteinemia are relatively rare,few guidelines for their diagnosis and treatment have been established; however,type i and v hyperlipoproteinemia are clinically important as underlying disorders of acute pancreatitis,and appropriate management is necessary to prevent or treat such complications. against such a background,here we propose guidelines primarily concerning the diagnosis and management of type i and v hyperlipoproteinemia in japanese.
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کلیدواژه
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Chylomicronemia; Gene mutation; Hyperlipidemia; Lipase; Triglyceridemia
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آدرس
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department of clinical and molecular epidemiology,22nd century medical and research center,university of tokyo hospital,tokyo, Japan, internal medicine,sakura hospital,school of medicine,toho university,chiba, Japan, department of child health and welfare (pediatrics),faculty of medicine,university of the ryukyus,okinawa, Japan, department of lipidology,kanazawa university graduate school of medical science,kanazawa, Japan, department of biochemistry,nagoya city university graduate school of medical sciences,nagoya,japan,food and nutritional sciences,college of biosciences and biotechnology,chubu university,aichi, Japan, division of endocrinology and metabolism,department of medicine,nippon medical school,tokyo, Japan, department of genome research and clinical application,chiba university graduate school of medicine,chiba, Japan, division of endocrinology and metabolism,diabetes center,department of medicine,jichi medical university graduate school of medicine,tochigi, Japan, department of human health sciences,kyoto university graduate school of medicine,kyoto, Japan, department of cardiovascular medicine,osaka university graduate school of medicine,osaka, Japan, department of molecular innovation in lipidology,national cerebral and cardiovascular center research institute,osaka, Japan, school of pharmaceutical sciences,ohu university and department of medicine,ohu university hospital,fukushima, Japan, department of geriatrics,nagoya university graduate school of medicine,nagoya, Japan, department of internal medicine,university of tsukuba institute of clinical medicine,ibaraki, Japan, department of endocrinology and metabolism,graduate school of comprehensive human sciences,university of tsukuba,ibaraki, Japan, university of tsukuba,ibaraki, Japan
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Authors
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