Lipoprotein(a) complexes with Beta2-Glycoprotein I in patients with coronary artery disease

Aim: to investigate the possible mechanisms and association of increased complexes of β 2-glycoprotein i with lipoprotein(a) [β 2-gpi-lp(a)] levels with the presence and extent of coronary artery disease (cad). methods: β 2-gpi-lp(a) levels were measured in 116 patients with acute coronary syndromes (acs),72 patients with stable cad and 100 control subjects. results: compared to the control,β 2-gpi-lp(a) levels (expressed after logarithmically transformation: acs,0.22±0.45 u/ml; stable cad,0.05±0.55 u/ml; control,-0.31±0.61 u/ml) significantly increased in both patients with acs (p<0.001) and stable cad (p<0.001). univariate logistic regression analysis of risk factors revealed that the presence of β 2-gpi-lp(a),ox-lp(a) or lp(a) was a strong risk factor for stable cad [β 2gpi-lp(a),or 3.17,95% ci 1.65,6.07; ox-lp(a),or 2.54,95% ci 1.33,4.85; lp(a),or 3.00,95% ci 1.56,5.75; respectively],and especially for acs [β 2-gpi-lp(a),or 5.38,95% ci 2.97,9.74; ox-lp(a),or 7.55,95% ci 4.12,13.84; lp(a),or 4.33,95% ci 2.40,7.80; respectively]. in multivariate analysis,adjusting for age,sex and plasma lipid levels,the presence of β 2-gpi-lp(a) or lp(a) was a risk factor for both stable cad and acs. ox-lp(a) was a risk factor only for acs,while not for stable cad. β 2-gpi-lp(a) levels were found to be positively associated with lp(a),ox-lp(a),maximal stenosis and a number of vessel diseases in patients with acs or stable cad,respectively. multiple linear regression analysis found that ox-lp(a) and maximal stenosis accounted for 46.2% of the variation in β 2-gpi-lp(a) levels. conclusions: elevated levels of β 2-gpi-lp(a) are associated with the presence and severity of cad,and may be a strong risk factor for atherosclerosis.