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Cardio-ankle vascular index in heterozygous familial hypercholesterolemia
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نویسنده
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soska v. ,dobsak p. ,dusek l. ,shirai k. ,jarkovsky j. ,novakova m. ,brhel p. ,stastna j. ,fajkusova l. ,freiberger t. ,yambe t.
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منبع
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journal of atherosclerosis and thrombosis - 2012 - دوره : 19 - شماره : 5 - صفحه:453 -461
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چکیده
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Aim: the cardio-ankle vascular index (cavi) is a new non-invasive marker of arterial stiffness and atherosclerosis. the purpose of this study was to compare cavi in patients with heterozygous familial hypercholesterolemia (fh) and in healthy controls. methods: 82 fh subjects (27 males,65 females),aged 53.7±13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males,238 females),aged 43.9±14.9 years,were examined. cavi was measured using the system vasera® 1500. results: cavi in fh patients was significantly higher (8.0 ± 1.4) than in healthy subjects (7.5± 1.3) p = 0.002; however,age,sex and bmi adjusted cavi did not differ significantly (p = 0.061) between the fh group (7.5,ci: 7.3; 7.7) and control group (7.7,ci: 7.6; 7.7). conclusion: the study showed no significant difference in cavi between heterozygous fh and healthy controls.
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کلیدواژه
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Atherosclerosis; Cardio-ankle vascular index; Ezetimibe; Familial hypercholesterolemia; Statins
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آدرس
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2nd clinic of internal medicine,masaryk university of brno,brno,czech republic,department of biochemistry,masaryk university of brno,brno, Czech Republic, department of sports medicine and rehabilitation,st. anne's faculty hospital,masaryk university of brno,brno, Czech Republic, institute of biostatistics and analyses,faculty of medicine and faculty of science,masaryk university,brno, Czech Republic, internal medicine,sakura hospital,medical center,toho university,chiba, Japan, institute of biostatistics and analyses,faculty of medicine and faculty of science,masaryk university,brno, Czech Republic, department of physiology,faculty of medicine,masaryk university of brno,brno, Czech Republic, department of occupational medicine,st. anne's faculty hospital,masaryk university of brno,brno, Czech Republic, children's department of internal medicine,faculty of medicine,masaryk university brno,brno, Czech Republic, center of molecular biology and gene therapy,university hospital brno,brno, Czech Republic, molecular genetics laboratory,centre for cardiovascular surgery and transplantation,brno, Czech Republic, department of medical engineering and cardiology,institute of development,aging and cancer,tohoku university,miyagi, Japan
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Authors
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