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There's more to flow-mediated dilation than nitric oxide
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نویسنده
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stoner l. ,erickson m.l. ,young j.m. ,fryer s. ,sabatier m.j. ,faulkner j. ,lambrick d.m. ,mccully k.k.
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منبع
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journal of atherosclerosis and thrombosis - 2012 - دوره : 19 - شماره : 7 - صفحه:589 -600
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چکیده
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Flow-mediated dilation (fmd) is the standard tool used to assess endothelial function. the premise behind the standard fmd test is that it serves as an endothelial-dependant nitric oxide bioassay; however,the endothelium may release additional dilatory molecules which contribute to fmd,most notably prostacyclin and endothelial-derived hyperpolarizing factor. the relative importance of these molecules to the dilatory response may vary substantially among individuals,particularly in response to a number of diseased states. this review discusses how each of these molecules may contribute to vasodilation,and considers the circumstances in which they may vary.
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کلیدواژه
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Cardiovascular disease; Endothelial-derived hyperpolarizing factor; Endothelium; FMD; Prostacyclin; Shear stress
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آدرس
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school of sport and exercise,massey university,wellington, New Zealand, department of kinesiology,university of georgia,ramsey center,athens,ga, United States, lipid and diabetes research group,diabetes research institute,christchurch hospital,christchurch, New Zealand, school of sciences and physical education,university of canterbury,christchurch, New Zealand, emory university rehabilitation medicine,atlanta,ga, United States, school of sport and exercise,massey university,wellington, New Zealand, institute of food nutrition and human health,massey university,wellington, New Zealand, department of kinesiology,university of georgia,ramsey center,athens,ga, United States
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Authors
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