Cannabinoid receptor 1 (CNR1) 4895 C/T genetic polymorphism was associated with obesity in Japanese men

Aim: the aim of this study was to investigate the association of cannabinoid receptor 1 (cnr1) 4895 c/t gene polymorphism with obesity and obesity-related cardiovascular disease (cvd) risk factors in japanese. method: this study included 1,452 japanese (678 men and 774 women,aged 25 to 74) from rural communities in shimane prefecture,japan. results: the frequency of the c minor allele of cnr1 4895 c/t polymorphism was 47%. in men,the cc genotype carriers showed significantly greater body mass index (bmi) and waist circumference (wc) values than t allele carriers,even after adjusting for age and medications for hypertension,dyslipidemia and type 2 diabetes. the frequency of obesity (bmi ≥25 kg/m2) in cc genotype carriers was significantly greater than in t allele carriers (31.8% vs 21.5%),but the frequency of central obesity (wc ≥ 85 for men and wc ≥90 cm for women) was not significant by cnr1 4895 c/t genotype. cc genotype carriers of cnr1 4895 c/t showed,in logistic regression analysis,significantly greater odds for obesity than t allele carriers,even after adjustment for age and the abovementioned medications. systolic blood pressure (sbp) values were also significantly different between the cc genotype and t allele carriers after controlling for age,medications for hypertension,dyslipidemia,and type 2 diabetes,and bmi or wc. conclusion: this study supports the association of cnr1 4895 c/t with interindividual differences in obesity in men.