Association between urinary 8-hydroxydeoxyguanosine,an indicator of oxidative stress,and the cardio-ankle vascular index in hypertensive patients

Aims: oxidative stress has been recently postulated to be an important factor in the pathogenesis and development of arteriosclerosis. although urinary 8-hydroxydeoxyguanosine (8-ohdg) is clinically used as a marker of oxidative stress,its usefulness in diagnosing arteriosclerosis has not been fully examined. this study aimed to evaluate the association between urinary 8-ohdg and the cardioankle vascular index (cavi) as a marker of arterial stiffness in hypertensive patients. methods: we enrolled 100 hypertensive patients (70±10 years) who had been taking antihypertensive medications for at least one year. urinary 8-ohdg levels were measured by an immunochromatographic assay (icr-001; selista inc.,tokyo,japan). cavis were measured at the same visit. results: urinary 8-ohdg was correlated with smoking habits (r =0.382,p<0.001) and cavis (r =0.223,p= 0.026). multiple linear regression analysis revealed two independent determinants of urinary 8-ohdg: smoking habits (β=0.501,p<0.001) and cavi (β=0.325,p= 0.001). in addition,cavis were correlated with age (r =0.600,p<0.001),bmi (r =-0.348,p<0.001),systolic blood pressure (r =0.343,p<0.001),pulse pressure (r =0.358,p<0.001),serum creatinine level (r =0.408,p<0.001),urinary 8-ohdg level (r =0.223,p=0.026),and diabetes (r =0.210,p=0.036). multiple linear regression analysis revealed two independent determinants of cavi: age (β=0.568,p<0.001) and 8-ohdg (β=0.357,p<0.001). conclusion: elevated cavi is independently associated with an elevated urinary 8-ohdg level in hypertensive patients.