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   Adherence to preferable behavior for lipid control by high-risk dyslipidemic Japanese patients under pravastatin treatment: the APPROACH-J study  
   
نویسنده kitagawa y. ,teramoto t. ,daida h.
منبع journal of atherosclerosis and thrombosis - 2012 - دوره : 19 - شماره : 9 - صفحه:795 -805
چکیده    Aim: we evaluated the impact of adherence to preferable behavior on serum lipid control assessed by a self-reported questionnaire in high-risk patients taking pravastatin for primary prevention of coronary artery disease. methods: high-risk patients taking pravastatin were followed for 2 years. questionnaire surveys comprising 21 questions,including 18 questions concerning awareness of health,and current status of diet,exercise,and drug therapy,were conducted at baseline and after 1 year. potential domains were established by factor analysis from the results of questionnaires,and adherence scores were calculated in each domain. the relationship between adherence scores and lipid values during the 1-year treatment period was analyzed by each domain using multiple regression analysis. results: a total of 5,792 patients taking pravastatin were included in the analysis. multiple regression analysis showed a significant correlation in terms of intake of high fat/cholesterol/sugar foods (regression coefficient -0.58,p=0.0105) and adherence to instructions for drug therapy (regression coefficient -6.61,p<0.0001). low-density lipoprotein cholesterol (ldl-c) values were significantly lower in patients who had an increase in the adherence score in the awareness of health domain compared with those with a decreased score. there was a significant correlation between high-density lipoprotein (hdl-c) values and awareness of health (regression coefficient 0.26; p=0.0037),preferable dietary behaviors (regression coefficient 0.75; p<0.0001),and exercise (regression coefficient 0.73; p=0.0002). similar relations were seen with triglycerides. conclusion: in patients who have a high awareness of their health,a positive attitude toward lipidlowering treatment including diet,exercise,and high adherence to drug therapy,is related with favorable overall lipid control even in patients under treatment with pravastatin.
کلیدواژه Adherence; Dyslipidemia; LDL cholesterol; Pravastatin
آدرس department of neurology,tokai university hachioji hospital,tokyo, Japan, department of internal medicine,teikyo university school of medicine,tokyo, Japan, department of cardiovascular medicine,juntendo university,school of medicine,tokyo, Japan
 
     
   
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