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   Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the suita study  
   
نویسنده arai h. ,kokubo y. ,watanabe m. ,sawamura t. ,ito y. ,minagawa a. ,okamura t. ,miyamato y.
منبع journal of atherosclerosis and thrombosis - 2013 - دوره : 20 - شماره : 2 - صفحه:195 -203
چکیده    Aim: several lines of evidence indicate that small dense low-density lipoproteins (sd-ldl) are more atherogenic than large buoyant ldl; however,few prospective studies have addressed the role of sd-ldl in cardiovascular disease (cvd). we therefore examined the association between sd-ldl cholesterol (sd-ldl-c) and cvd in a japanese cohort. methods: an 11.7-year prospective study was performed using a general population aged 30-79 without a history of cardiovascular disease. direct ldl-c and sd-ldl-c were measured in samples from 2034 participants (968 men and 1066 women). results: during the follow-up period,there were 116 incident cases of cvd. the multivariableadjusted hazard ratios (hrs) of sd-ldl-c for cvd were calculated using a proportional hazards regression model after adjusting for age,hypertension,diabetes,use of lipid-lowering drugs,body mass index,and current smoking and alcohol drinking,and found that increasing quartiles of sd-ldl-c were associated with increased risk of cvd. we also determined that age and sex-adjusted hrs per 10 mg/dl of sd-ldl-c and hrs for cvd,stroke,cerebral infarction,and coronary artery disease were 1.21 (95% ci: 1.12-1.31),1.17 (95% ci: 1.05-1.30),1.15 (95% ci: 1.00-1.33),and 1.29 (95% ci: 1.14-1.45),respectively. conclusions: it was demonstrated that sd-ldl-c was significantly associated with cvd in a japanese population,providing evidence of sd-ldl-c as an important biomarker to predict cvd.
کلیدواژه Cardiovascular disease; Epidemiology; Lipids; Lipoproteins; Risk factors
آدرس department of human health sciences,kyoto university graduate school of medicine,kyoto, Japan, department of preventive cardiology,national cerebral and cardiovascular center,suita, Japan, department of preventive cardiology,national cerebral and cardiovascular center,suita, Japan, department of vascular physiology,national cerebral and cardiovascular center,suita, Japan, research and development department,denka seiken,tokyo, Japan, research and development department,denka seiken,tokyo, Japan, department of preventive medicine and public health,school of medicine,keio university,tokyo, Japan, department of preventive cardiology,national cerebral and cardiovascular center,suita, Japan
 
     
   
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