Simultaneous ingestion of fructose and fat exacerbates postprandial exogenous lipidemia in young healthy Japanese women

Aim: to investigate the acute effects of the simultaneous ingestion of fructose and fat on postprandial lipoprotein metabolism in healthy young women. methods: nine young healthy japanese women with a normal weight (body mass index: 18.5 ≤-< 25 kg/m2),a normal ovarian cycle and an apolipoprotein e 3/3 phenotype were enrolled as participants and studied on four occasions. at each session,the subjects ingested one of four beverages containing either glucose or fructose (0.5 g/kg body weight each) with or without oftt cream (1 g/kg,0.35 g/ kg as fat) in a randomized crossover design. blood samples were collected at baseline and at 0.5,1,2,4 and 6 hours after ingestion. results: the ingestion of fructose combined with fat led to significantly higher rises in the serum triglyceride (tg),remnant-like particle (rlp)-tg,remnant lipoprotein-cholesterol (reml-c) and apolipoprotein b-48 (apob48) concentrations with delayed peaks compared with that observed following ingestion of the other three types of beverages. the incremental area under the curve ({right triangle} auc)-tg and {right triangle}auc-apob48 were larger than those observed for the ingestion of fat only. the serum rlp-tg and apob48 concentrations returned to the fasting levels (0 hours) at the end of the test (6 hours) following the ingestion of fat only; however,these concentrations did not return to the fasting levels following the intake of fructose combined with fat. conclusions: these findings suggest a delay in the clearance of intestinal tg-rich lipoproteins,namely chylomicron and its remnant,following the ingestion of fructose combined with fat. the simultaneous ingestion of fructose and fat markedly enhances postprandial exogenous lipidemia in young healthy japanese women.