Circulating TNF receptor 2 is closely associated with the kidney function in non-diabetic Japanese subjects

Aim: chronic kidney disease (ckd) is associated with cardiovascular events. tumor necrosis factor (tnf) and/or its receptors have been postulated to be involved in renal pathophysiology. it is unclear whether an increased tnf system activity is present before the development of apparent ckd. methods: four hundred and twenty non-diabetic japanese subjects with an estimated gfr (egfr) greater than 60 ml/min/1.73 m2 were recruited for measurement of the hba1c,insulin,tnf system activity (tnf-α,soluble tnf receptor 1 (stnf-r1) and stnf-r2) levels and various parameters,including the lipid,high-sensitivity c-reactive protein (hscrp),high-molecular-weight (hmw) adiponectin and leptin levels. the subjects were stratified according to the egfr: the g1 level (egfr ≥90 ml/min/1.73 m2) and the g2 level (90 <egfr ≥60 ml/min/1.73 m2). results: whereas no significant differences were observed in gender,body mass index (bmi),blood pressure,insulin,tnf-α,hscrp,hmw adiponectin or leptin between the two groups,the values for age,hba1c,triglycerides,stnf-r1 and stnf-r2 were significantly higher in the subjects with a g2 level of egfr than in those with a g1 level. in contrast,the hdl cholesterol levels were significantly lower in the subjects with a g2 level than in those with a g1 level. linear negative correlations were also observed between egfr and age,bmi,hba1c,triglycerides,stnf-r1 and stnfr2,respectively. a multiple logistic regression analysis revealed that only stnf-r2 was associated with the presence of a g2 level of egfr (odds ratio 1.092,95% ci 1.013-1.177,p= 0.021). conclusions: the circulating stnf-r2 level is closely associated with the kidney function in nondiabetic japanese subjects.